Minima concentrazione antibiotica

La minima concentrazione antibiotica o MAC (dall'acronimo in lingua inglese minimal antibiotic concentration) è un termine utilizzato in microbiologia per indicare la minima concentrazione di farmaco antibiotico in grado di ridurre la crescita batterica di 1 log (oltre il 90%) in una determinata quantità di tempo, comparata con una coltura batterica di controllo[1][2].

L'indice è stato proposto per descrivere il comportamento dei batteri a basse concentrazioni di antibiotico, in contrasto con la concentrazione minima inibitoria (MIC) che ne studia gli effetti ad alte dosi[3]. Può essere utilizzato anche nel rapporto MIC/MAC per valutare l'attività antibatterica a concentrazioni subminimali[4].

Tale indice non ha avuto tuttavia una grande diffusione, in quanto gli è preferito lo stesso MIC.

Note

  1. ^ (EN) Schrire, et al., Activities of Four Aminoglycosides at Subbactericidal Concentrations, in Antimicrob Agents Chemother, vol. 22, n. 1, 1982.
  2. ^ (EN) Greenwood D, Interactions between antibacterial drugs below the minimal inhibitory concentration., in Rev Infect Dis, vol. 1, n. 5, 1979, pp. 807-12.
  3. ^ (EN) Lorian V, De Fraitas CC, Minimal antibiotic concentrations of aminoglycosides and beta-lactam antibiotics for some gram-negative bacilli and gram-positive cocci., in J Infect Dis, vol. 139, n. 5, 1979, pp. 599-603.
  4. ^ (EN) Erzow, et al, Range of antibacterial activity of antibiotics at subminimal inhibitory concentrations: the ratio of minimal inhibitory concentration to minimal antibiotic concentration., in Rev Infect Dis, vol. 1, n. 5, 1979, pp. 821-4.

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