8-ossocoformicina reduttasi

8-ossocoformicina reduttasi
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Numero EC1.1.1.235
ClasseOssidoreduttasi
Nome sistematico
coformicina:NADP+ 8-ossidoreduttasi
Altri nomi
8-chetodeossicoformicina reduttasi
Banche datiBRENDA, EXPASY, GTD, PDB (RCSB PDB PDBe PDBj PDBsum)
Fonte: IUBMB

La 8-ossocoformicina reduttasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione:

coformicina + NADP+ 8-ossocoformicina + NADPH + H+

L'enzima è B-specifico rispetto a NADPH. Esso è in grado di ridurre anche l'8-ossodeossi-coformicina all'antibiotico nucleosidico deossicoformicina.

Bibliografia

  • Hanvey, J.C., Hawkins, E.S., Baker, D.C. and Suhadolnick, R.J., 8-Ketodeoxycoformycin and 8-ketocoformycin as intermediates in the biosynthesis of 2′-deoxycoformycin and coformycin, in Biochemistry, vol. 27, 1988, pp. 5790–5795, Entrez PubMed 3052586.
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