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4-idrossibenzoil-CoA reduttasi
La 4-idrossibenzoil-CoA reduttasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione:
- benzoil-CoA + accettore + H2O ⇄ 4-idrossibenzoil-CoA + accettore ridotto
Una flavoproteina molibdeno-ferro-zolfo che è coinvolta nella via anaerobica del metabolismo dei fenoli nei batteri. La ferrodoxina con due gruppi [4Fe-4S] funge da naturale donatore di elettroni (3).
Bibliografia
- Heider, J. and Fuchs, G., Anaerobic metabolism of aromatic compounds, in Eur. J. Biochem., vol. 243, 1997, pp. 577–596, Entrez PubMed 9057820.
- Brackmann, R. and Fuchs, G., Enzymes of anaerobic metabolism of phenolic compounds. 4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from a denitrifying Pseudomonas species, in Eur. J. Biochem., vol. 213, 1993, pp. 563–571, Entrez PubMed 8477729.
- Breese, K. and Fuchs, G., 4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from the denitrifying bacterium Thauera aromatica - prosthetic groups, electron donor, and genes of a member of the molybdenum-flavin-iron-sulfur proteins, in Eur. J. Biochem., vol. 251, 1998, pp. 916–923, Entrez PubMed 9490068.
- Heider, J., Boll, M., Breese, K., Breinig, S., Ebenau-Jehle, C., Feil, U., Gad'on, N., Laempe, D., Leuthner, B., Mohamed, M.E.S., Schneider, S., Burchhardt, G. and Fuchs, G., Differential induction of enzymes involved in anaerobic metabolism of aromatic compounds in the denitrifying bacterium Thauera aromatica, in Arch. Microbiol., vol. 170, 1998, pp. 120–131, Entrez PubMed 9683649.
- Glockler, R., Tschech, A. and Fuchs, G., Reductive dehydroxylation of 4-hydroxybenzoyl-CoA to benzoyl-CoA in a denitrifying, phenol-degrading Pseudomonas species, in FEBS Lett., vol. 251, 1989, pp. 237–240, Entrez PubMed 2753161.
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