Erytromysiini

Erytromysiini
Erytromysiini
Systemaattinen (IUPAC) nimi
6-(4-dimetyyliamino-3-hydroksi-6-metyyli-oksan-2-yyli)oksi-14-etyyli-7,12,13-trihydroksi-

4-(5-hydroksi-4-metoksi-4,6-dimetyyli-oksan-2-yyli)oksi-3,5,7,9,11,13-heksametyyli-1-oksasyklotetradekaani-2,10-dioni

Tunnisteet
CAS-numero 114-07-8
ATC-koodi J01FA01
PubChem CID 3255
DrugBank APRD00953
Kemialliset tiedot
Kaava C37H67NO13 
Moolimassa 733.93 g/mol
Farmakokineettiset tiedot
Hyötyosuus 100 %
Proteiinisitoutuminen 90 %
Metabolia maksa (alle 5 % erittyy muuttumattomana)
Puoliintumisaika 1.5 tuntia
Ekskreetio sappi
Terapeuttiset näkökohdat
Raskauskategoria

A(AU) B(US)

Reseptiluokitus

Prescription Only (S4) (AU)?-only(US)

Antotapa oraalinen, intravenoosinen, intramuskulaarinen

Erytromysiini on makrolideihin kuuluva bakteerien lisääntymistä estävä antibiootti, jota määrätään usein penisilliinille allergisille potilaille. Erytromysiinin kemiallinen kaava on C37H67NO13, moolimassa 733,93 g/mol ja CAS-numero 114-07-8.

Erytromysiini tuli kaupalliseen myyntiin vuonna 1952 tuotenimellä Ilosone®. Aineen käyttö raskauden alkuvaiheessa ei ole suositeltavaa, sillä sen on arveltu voivan altistaa sikiötä sydänvioille.[1] Erytromysiinin käyttö samanaikaisesti sen hajoamista estävän lääkkeen kanssa johtaa elimistön liian korkeaan erytromysiinipitoisuuteen, josta seurauksena voi pahimmillaan olla sydämenpysähdys.[2]

Erytromysiini metaboloituu pääasiassa maksassa. Tavallisimpia mahdollisia sivuvaikutuksia ovat ripuli, pahoinvointi, vatsakipu ja oksentelu. Lääkkeellä voidaan hoitaa mm. keuhkoputken ja poskiontelon bakteeritulehduksia.

Lähteet

  1. ↑ Erpo Pakkala: Erytromysiini voi aiheuttaa sikiölle sydänhaittoja 7. heinäkuuta 2005. Mediuutiset. Arkistoitu 27.9.2007. Viitattu 3. toukokuuta 2007.
  2. ↑ Erytromysiini voi pysäyttää sydämen 12. joulukuuta 2004. Positiiviset ry. Arkistoitu 26.9.2007. Viitattu 3. toukokuuta 2007.

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