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BLK
معین‌کننده‌ها
نام‌های دیگر	BLK, MODY11, BLK proto-oncogene, Src family tyrosine kinase
شناسه‌های بیرونی	OMIM: 191305 MGI: 88169 HomoloGene: 1297 GeneCards: BLK
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۴ (موش)
پایان	63,654,486 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• transferase activity; • nucleotide binding; • protein kinase activity; • non-membrane spanning protein tyrosine kinase activity; • kinase activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • protein tyrosine kinase activity; • signaling receptor binding; • ATP binding;
ترکیبات سلولی	• membrane; • extrinsic component of cytoplasmic side of plasma membrane; • پوسته یاخته; • سیتوزول;
فرایند زیستی	• B cell receptor signaling pathway; • دگرگونی یاخته‌; • GO:0007243 intracellular signal transduction; • فسفرگیری; • transmembrane receptor protein tyrosine kinase signaling pathway; • protein phosphorylation; • regulation of cell population proliferation; • peptidyl-tyrosine autophosphorylation; • دستگاه ایمنی ذاتی; • positive regulation of insulin secretion; • کوچ یاخته; • regulation of B cell receptor signaling pathway; • peptidyl-tyrosine phosphorylation;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	640
	12143
	ENSG00000136573; ENSG00000285369
	ENSMUSG00000014453
	P51451
	P16277
	NM_001715، XM_011543824، XM_011543825، XM_011543827، XM_011543828، NM_001330465، XM_047422081، XM_047422082، XM_047422083، XM_047422084 XM_011543829، NM_001715، XM_011543824، XM_011543825، XM_011543827، XM_011543828، NM_001330465، XM_047422081، XM_047422082، XM_047422083، XM_047422084
	NM_007549
	NP_001706، XP_011542126، XP_011542127، XP_011542129، XP_011542130، XP_011542131 NP_001317394، NP_001706، XP_011542126، XP_011542127، XP_011542129، XP_011542130، XP_011542131
	NP_031575
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

تیروزین-پروتئین کیناز BLK (انگلیسی: Tyrosine-protein kinase BLK) که با نام کیناز لنفوسیت بی هم شناخته می‌شود، یک آنزیم است که در انسان توسط ژن «BLK» کدگذاری می‌شود.^[۴]^[۵]

این آنزیم، با مولکول UBE3A تعامل پروتئین-پروتئین دارد.^[۶]

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000014453 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Drebin JA, Hartzell SW, Griffin C, Campbell MJ, Niederhuber JE (Mar 1995). "Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk)". Oncogene. 10 (3): 477–86. PMID 7845672.
↑ "Entrez Gene: BLK B lymphoid tyrosine kinase".
↑ Oda H, Kumar S, Howley PM (August 1999). "Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9557–62. doi:10.1073/pnas.96.17.9557. PMC 22247. PMID 10449731.

مشارکت‌کنندگان ویکی‌پدیا. «Tyrosine-protein kinase BLK». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۵ اوت ۲۰۱۹.

برای مطالعهٔ بیشتر

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Oda H, Kumar S, Howley PM (1999). "Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9557–62. doi:10.1073/pnas.96.17.9557. PMC 22247. PMID 10449731.
Appel S, Filter M, Reis A, et al. (2002). "Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759". Eur. J. Hum. Genet. 10 (1): 17–25. doi:10.1038/sj.ejhg.5200750. PMID 11896452.
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Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cho JY, Akbarali Y, Zerbini LF, et al. (2004). "Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene". J. Biol. Chem. 279 (19): 19512–22. doi:10.1074/jbc.M309074200. PMID 14970218.