اینتگرین آلفا ۴

ITGA4
ساختارهای موجود PDB جستجوی هم‌ساخت‌شناسی: PDBe RCSB فهرست شناسه‌های PDB 4HKC, 3V4P, 3V4V, 5FPI, 5C7Z
معین‌کننده‌ها
نام‌های دیگر	ITGA4, CD49D, IA4, integrin subunit alpha 4
شناسه‌های بیرونی	OMIM: 192975 MGI: 96603 HomoloGene: 37364 GeneCards: ITGA4
موقعیت ژن (موش) کروموزوم کروموزوم ۲ (موش)[۱] نوار 2 C3|2 47.38 cM شروع 79,085,770 bp[۱] پایان 79,163,467 bp[۱]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • GO:0001948، GO:0016582 پیوند پروتئینی • protein antigen binding • metal ion binding • GO:0003823، GO:0051635 antigen binding • fibronectin binding • cell adhesion molecule binding • coreceptor activity • C-X3-C chemokine binding • protein heterodimerization activity ترکیبات سلولی • extracellular exosome • integral component of membrane • membrane • focal adhesion • cell surface • integrin alpha4-beta7 complex • integrin complex • پوسته یاخته • growth cone • soma • GO:0009327 protein-containing complex فرایند زیستی • endodermal cell differentiation • B cell differentiation • positive regulation of T cell migration • extracellular matrix organization • heterotypic cell-cell adhesion • substrate adhesion-dependent cell spreading • cellular response to cytokine stimulus • cell-matrix adhesion involved in ameboidal cell migration • cell-matrix adhesion • leukocyte tethering or rolling • دیاپدز • regulation of immune response • integrin-mediated signaling pathway • leukocyte migration • positive regulation of leukocyte tethering or rolling • positive regulation of leukocyte cell-cell adhesion • positive regulation of leukocyte migration • import into cell • leukocyte cell-cell adhesion • negative regulation of protein homodimerization activity • clathrin-dependent extracellular exosome endocytosis • چسبندگی سلولی • receptor clustering • cell-cell adhesion mediated by integrin • axonogenesis involved in innervation • cell-cell adhesion in response to extracellular stimulus • cellular response to amyloid-beta • positive regulation of vascular endothelial cell proliferation • neuron projection extension • positive regulation of endothelial cell apoptotic process منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	3676	16401
آنسامبل	ENSG00000115232	ENSMUSG00000027009
یونی‌پروت	P13612	Q00651
RefSeq (mRNA)	NM_001316312 NM_000885، NM_001316312	XM_036158647 NM_010576، XM_036158647
RefSeq (پروتئین)	NP_001303241 NP_000876، NP_001303241	XP_036014540 NP_034706، XP_036014540
موقعیت (UCSC)	ن/م	Chr : 79.09 – 79.16 Mb
جستجوی PubMed	[۲]	[۳]
ویکی‌داده
مشاهده/ویرایش انسان مشاهده/ویرایش موش

اینتگرین آلفا ۴ (انگلیسی: Integrin alpha 4) نوعی پروتئین و همچنین زیرواحد آلفای اینتگرین است که نیمی از گیرندهٔ لنفوسیتی α4β1 را تشکیل می‌دهد.

زنجیرهٔ آلفا ۴ اینتگرین با «زنجیرهٔ بتا ۱» یا «زنجیرهٔ بتا ۷» از ارتباط است^[۴] و با گالکتین-۸^[۵] و پاکسیلین^[۶][۷] تعامل پروتئین-پروتئین دارد.

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000027009 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)".
5. Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y (2000). "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis". J. Cell Sci. 113 (Pt 13): 2385–97. PMID 10852818.
6. Han J, Liu S, Rose DM, Schlaepfer DD, McDonald H, Ginsberg MH (November 2001). "Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding". J. Biol. Chem. 276 (44): 40903–9. doi:10.1074/jbc.M102665200. PMID 11533025.
7. Liu S, Kiosses WB, Rose DM, Slepak M, Salgia R, Griffin JD, Turner CE, Schwartz MA, Ginsberg MH (June 2002). "A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration". J. Biol. Chem. 277 (23): 20887–94. doi:10.1074/jbc.M110928200. PMID 11919182.

• مشارکت‌کنندگان ویکی‌پدیا. «Integrin alpha 4». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۳ اوت ۲۰۱۹.

برای مطالعهٔ بیشتر

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پیوند به بیرون

• CD49d antigen در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا