SRI (ژن)

SRI
ساختارهای موجود PDB جستجوی هم‌ساخت‌شناسی: PDBe RCSB فهرست شناسه‌های PDB 1JUO, 2JC2, 4U8D, 4UPG, 4USL
معین‌کننده‌ها
نام‌های دیگر	SRI, CP-22, CP22, SCN, V19, sorcin
شناسه‌های بیرونی	OMIM: 182520 MGI: 98419 HomoloGene: 37736 GeneCards: SRI
موقعیت ژن (موش) کروموزوم کروموزوم ۵ (موش)[۱] نوار 5 A1|5 3.38 cM شروع 8,096,078 bp[۱] پایان 8,119,379 bp[۱]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • calcium ion binding • transmembrane transporter binding • calcium channel regulator activity • metal ion binding • calcium-dependent cysteine-type endopeptidase activity • protease binding • GO:0001948، GO:0016582 پیوند پروتئینی • protein heterodimerization activity • identical protein binding • signaling receptor binding ترکیبات سلولی • axon terminus • dendritic spine neck • ریزکیسه • سیتوزول • endoplasmic reticulum membrane • membrane • لولچه عرضی • پوسته یاخته • intracellular anatomical structure • شبکه سارکوپلاسمی • نوکلئوپلاسم • smooth endoplasmic reticulum • آسه • chromaffin granule membrane • Z discdkac • میتوکندری • sarcoplasmic reticulum membrane • extracellular exosome • سیتوپلاسم فرایند زیستی • regulation of calcium ion transport • regulation of heart contraction • cytoplasmic sequestering of transcription factor • muscle organ development • positive regulation of release of sequestered calcium ion into cytosol • negative regulation of heart rate • پروتئین‌کافت • negative regulation of ryanodine-sensitive calcium-release channel activity • regulation of cardiac muscle cell contraction • heart development • intracellular sequestering of iron ion • regulation of striated muscle contraction • negative regulation of transcription regulatory region DNA binding • regulation of high voltage-gated calcium channel activity • پتانسیل عمل • positive regulation of insulin secretion involved in cellular response to glucose stimulus • regulation of cell communication by electrical coupling • regulation of cell communication by electrical coupling involved in cardiac conduction • regulation of relaxation of muscle • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • calcium ion transport • GO:0072468 ورارسانی پیام • negative regulation of cardiac muscle contraction • GO:0015915 transport منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	6717	109552
آنسامبل	ENSG00000075142	ENSMUSG00000003161
یونی‌پروت	P30626	Q6P069
RefSeq (mRNA)	NM_001256892، NM_003130، NM_198901 NM_001256891، NM_001256892، NM_003130، NM_198901	NM_025618، XM_006503527، XM_017320600 NM_001080974، NM_025618، XM_006503527، XM_017320600
RefSeq (پروتئین)	NP_001243821، NP_003121، NP_944490، XP_011514830 NP_001243820، NP_001243821، NP_003121، NP_944490، XP_011514830	NP_079894، XP_006503590، XP_017176089 NP_001074443، NP_079894، XP_006503590، XP_017176089
موقعیت (UCSC)	ن/م	Chr : 8.1 – 8.12 Mb
جستجوی PubMed	[۲]	[۳]
ویکی‌داده
مشاهده/ویرایش انسان مشاهده/ویرایش موش

سورسین پروتئینی است که در انسان توسط ژن SRI کدگذاری می‌شود.^[۴][۵]

فعل و انفعالات

مشخص شده‌است که ژن SRI با گیرنده‌های رایانودین ۲،^[۶] ANXA7^[۷] و GCA تعامل پروتئین-پروتئین دارد.^[۸]

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000003161 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Van der Bliek AM, Baas F, Van der Velde-Koerts T, Biedler JL, Meyers MB, Ozols RF, Hamilton TC, Joenje H, Borst P (November 1988). "Genes amplified and overexpressed in human multidrug-resistant cell lines". Cancer Research. 48 (21): 5927–32. PMID 2901906.
5. "Entrez Gene: SRI sorcin".
6. Meyers MB, Pickel VM, Sheu SS, Sharma VK, Scotto KW, Fishman GI (November 1995). "Association of sorcin with the cardiac ryanodine receptor". The Journal of Biological Chemistry. 270 (44): 26411–8. doi:10.1074/jbc.270.44.26411. PMID 7592856.
7. Brownawell AM, Creutz CE (August 1997). "Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII)". The Journal of Biological Chemistry. 272 (35): 22182–90. doi:10.1074/jbc.272.35.22182. PMID 9268363.
8. Hansen C, Tarabykina S, la Cour JM, Lollike K, Berchtold MW (June 2003). "The PEF family proteins sorcin and grancalcin interact in vivo and in vitro". FEBS Letters. 545 (2–3): 151–4. doi:10.1016/S0014-5793(03)00518-0. PMID 12804766.

جهت مطالعه

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