گیرنده ۱ هورمون آزادکننده کورتیکوتروپین

CRHR1
ساختارهای موجود PDB جستجوی هم‌ساخت‌شناسی: PDBe RCSB فهرست شناسه‌های PDB 4K5Y, 3EHU, 2L27, 3EHS, 3EHT, 4Z9G
معین‌کننده‌ها
نام‌های دیگر	CRHR1, CRF-R, CRF-R-1, CRF-R1, CRF1, CRFR-1, CRFR1, CRH-R-1, CRH-R1, CRH-R1h, CRHR, CRHR1L, CRHR1f, corticotropin releasing hormone receptor 1
شناسه‌های بیرونی	OMIM: 122561 MGI: 88498 HomoloGene: 20920 GeneCards: CRHR1
موقعیت ژن (موش) کروموزوم کروموزوم ۱۱ (موش)[۱] نوار 11 E1|11 67.77 cM شروع 104,023,681 bp[۱] پایان 104,066,349 bp[۱]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • G protein-coupled receptor activity • signal transducer activity • GO:0001948، GO:0016582 پیوند پروتئینی • corticotrophin-releasing factor receptor activity • transmembrane signaling receptor activity • peptide hormone binding • corticotropin-releasing hormone receptor activity • corticotropin-releasing hormone binding • G-protein alpha-subunit binding • peptide binding • GO:0032403 protein-containing complex binding ترکیبات سلولی • integral component of membrane • اندوزوم • membrane • intrinsic component of plasma membrane • پوسته یاخته • integral component of plasma membrane • multivesicular body • trans-Golgi network • دندریت • ریزکیسه • soma • apical part of cell فرایند زیستی • corticotropin secretion • female pregnancy • activation of adenylate cyclase activity • regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway • cell surface receptor signaling pathway • زایش • GO:0046730، GO:0046737، GO:0046738، GO:0046736 پاسخ ایمنی • cellular response to corticotropin-releasing hormone stimulus • regulation of corticosterone secretion • negative regulation of voltage-gated calcium channel activity • GO:0072468 ورارسانی پیام • G protein-coupled receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • hormone-mediated signaling pathway • response to hypoxia • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • neuropeptide signaling pathway • حافظه • رفتار تغذیه‌ای • یادگیری بصری • hypothalamus development • adrenal gland development • epithelial cell differentiation • negative regulation of epinephrine secretion • locomotory exploration behavior • response to immobilization stress • fear response • positive regulation of mast cell degranulation • positive regulation of cAMP-mediated signaling • behavioral response to cocaine • behavioral response to ethanol • regulation of synaptic plasticity • behavioral response to pain • response to electrical stimulus • general adaptation syndrome, behavioral process • تقویت طولانی مدت • negative regulation of neuron death • negative regulation of feeding behavior منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	1394	12921
آنسامبل	ن/م	ENSMUSG00000018634
یونی‌پروت	P34998	P35347
RefSeq (mRNA)	NM_001145147، NM_001145148، NM_004382، NM_001303018، NM_001303020 NM_001145146، NM_001145147، NM_001145148، NM_004382، NM_001303018، NM_001303020	NM_001313928، NM_001313929، XM_017314246، XR_001779869، XR_001779870، XR_001779871، XM_036156274، XM_036156275 NM_007762، NM_001313928، NM_001313929، XM_017314246، XR_001779869، XR_001779870، XR_001779871، XM_036156274، XM_036156275
RefSeq (پروتئین)	NP_001138619، NP_001138620، NP_001289947، NP_001289949، NP_004373 NP_001138618، NP_001138619، NP_001138620، NP_001289947، NP_001289949، NP_004373	NP_001300858، NP_031788، XP_017169735، XP_036012167، XP_036012168 NP_001300857، NP_001300858، NP_031788، XP_017169735، XP_036012167، XP_036012168
موقعیت (UCSC)	ن/م	Chr : 104.02 – 104.07 Mb
جستجوی PubMed	[۲]	[۳]
ویکی‌داده
مشاهده/ویرایش انسان مشاهده/ویرایش موش

گیرنده ۱ هورمون آزادکننده کورتیکوتروپین (انگلیسی: Corticotropin-releasing hormone receptor 1) که با نام CRF₁ هم شناخته می‌شود؛^[۴] یک پروتئین است که در انسان توسط ژن «CRHR1» کُدگذاری می‌شود.^[۵][۶]

این گیرنده به هورمون آزادکننده کورتیکوتروپین^[۷] یا آگونیست‌های CRF متصل می‌شود^{[۸][۹][۱۰]} و به میزان زیادی در دستگاه عصبی مرکزی و دستگاه عصبی پیرامونی بیان می‌شود.^[۱۰]

دگرگونی در این ژن با افزایش پاسخ به درمان کورتونی در مبتلایان به آسم^[۱۱] و احتمال بروز پرفشاری ریوی دائمی در نوزادان^[۱۲] همراه است.

جستارهای وابسته

• هورمون آزادکننده کورتیکوتروپین
• گیرنده هورمون آزادکننده کورتیکوتروپین

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000018634 - Ensembl, May 2017
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7. "Entrez Gene: CRHR1 corticotropin releasing hormone receptor 1".
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10. Grammatopoulos DK, Dai Y, Randeva HS, Levine MA, Karteris E, Easton AJ, Hillhouse EW (December 1999). "A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes". Molecular Endocrinology. 13 (12): 2189–202. doi:10.1210/mend.13.12.0391. PMID 10598591.
11. Tantisira KG, Lake S, Silverman ES, Palmer LJ, Lazarus R, Silverman EK, Liggett SB, Gelfand EW, Rosenwasser LJ, Richter B, Israel E, Wechsler M, Gabriel S, Altshuler D, Lander E, Drazen J, Weiss ST (July 2004). "Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids". Human Molecular Genetics. 13 (13): 1353–9. doi:10.1093/hmg/ddh149. PMID 15128701.
12. Byers HM, Dagle JM, Klein JM, Ryckman KK, McDonald EL, Murray JC, Borowski KS (February 2012). "Variations in CRHR1 are associated with persistent pulmonary hypertension of the newborn". Pediatric Research. 71 (2): 162–7. doi:10.1038/pr.2011.24. PMC 3718388. PMID 22258127.

• مشارکت‌کنندگان ویکی‌پدیا. «Corticotropin-releasing hormone receptor 1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲ ژانویه ۲۰۱۹.

برای مطالعهٔ بیشتر

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پیوند به بیرون

• Corticotropin-releasing hormone receptors در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا
• CRF receptor type 1 در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا