آزاستروئید

فیناستراید و دوتاستراید، دو داروی آزاستروئیدی هستند. اتم‌های نیتروژن در هر سیستم حلقه با رنگ قرمز مشخص شده‌اند.

آزاستروئید نوعی مشتق استروئیدی است که در آن، یکی از اتم‌های کربن موجود در سیستم حلقه استروئیدی با اتم نیتروژن جایگزین شده‌است. دو آزاستروئید، فیناستراید و دوتاستراید، از نظر بالینی به عنوان مهارکننده‌های ۵α-ردوکتاز استفاده می‌شوند.[۱][۲][۳]

برخی از ۶-آزاستروئیدها ممکن است به لحاظ دارویی مفیدی باشند، اما هنوز به صورت تجاری به بازار عرضه نشده‌اند.[۴][۵]

منابع

  1. ↑ Enrique Ravina (11 January 2011). The Evolution of Drug Discovery: From Traditional Medicines to Modern Drugs. John Wiley & Sons. pp. 183–. ISBN 978-3-527-32669-3.
  2. ↑ Roger S. Kirby; John D. McConnell; John M. Fitzpatrick; Claus G. Roehrborn; Peter Boyle (29 November 2004). Textbook of Benign Prostatic Hyperplasia, Second Edition. CRC Press. pp. 321–. ISBN 978-1-901865-55-4.
  3. ↑ Singh, Shankar; Gauthier, Sylvain; Labrie, Fernand (2000). "Androgen Receptor Antagonists (Antiandrogens) Structure-Activity Relationships". Current Medicinal Chemistry. 7 (2): 211–247. doi:10.2174/0929867003375371. ISSN 0929-8673. PMID 10637363.
  4. ↑ Frye, Stephen V.; Haffner, Curt D.; Maloney, Patrick R.; Mook, Robert A.; Dorsey, G. F.; Hiner, Roger N.; Batchelor, Kenneth W.; Bramson, H. Neal; Stuart, J. Darren (1993). "6-Azasteroids: Potent dual inhibitors of human type 1 and 2 steroid 5.alpha. -reductase". Journal of Medicinal Chemistry. 36 (26): 4313–5. doi:10.1021/jm00078a022. PMID 8277514.
  5. ↑ Frye, Stephen V.; Haffner, Curt D.; Maloney, Patrick R.; Mook, Robert A.; Dorsey, George F.; Hiner, Roger N.; Cribbs, Cindy M.; Wheeler, Thomas N.; Ray, John A. (1994). "6-Azasteroids: Structure-Activity Relationships for Inhibition of Type 1 and 2 Human 5.alpha. -Reductase and Human Adrenal 3.beta. -Hydroxy-.DELTA.5-steroid Dehydrogenase/3-Keto-.DELTA.5-steroid Isomerase". Journal of Medicinal Chemistry. 37 (15): 2352–60. doi:10.1021/jm00041a014. PMID 8057283.

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