The genus survived the Great American Interchange.[2] It had to compete with more derived relatives such as Macrauchenia, and may have occupied a specialised ecological niche to avoid competition. Its remains are found in subtropical areas, while other genera were found in tropical and temperate environment. As fossils of this genus are often found in association with aeolian deposits, corresponding with arid and semiarid environments, it is possible it occupied more similar with modern camels that its relative Macrauchenia.
^Schmidt, Gabriela I.; Ferrero, Brenda S. (September 2014). "Taxonomic Reinterpretation of Theosodon hystatus Cabrera and Kraglievich, 1931 (Litopterna, Macraucheniidae) and Phylogenetic Relationships of the Family". Journal of Vertebrate Paleontology. 34 (5): 1231–1238. Bibcode:2014JVPal..34.1231S. doi:10.1080/02724634.2014.837393. hdl:11336/18953. S2CID86091386.