Wynford sat as Member of Parliament for Mitchell (also known as St Michael's) between 1831 and 1832, when the constituency was disenfranchised through the Great Reform Act. He succeeded his father in the barony in 1845.
Lord Wynford died in February 1869, aged 71, at 7 Park Place, St James', Middlesex, and was succeeded in the barony by his eldest son, William Draper Mortimer Best, 3rd Baron Wynford.