Westmead station opened in March 1883.[3] To the east of the station lies a dive through which one of the eastbound tracks passes. This was opened in 1986 as part of the quadruplication of the Main Western line between Westmead and Granville. It was necessary because west of Westmead the two westbound tracks run adjacent to one another as do the two eastbound tracks. East of Westmead, the lines are configured to run as West/East/West/East.[4]
Between 1922 and 1932, the Rogans Hill line branched from the Main Western line immediately to the west of Westmead station.[5]
The station received an easy access upgrade prior to August 1997 which included tactile indicators, a lift to each platform and shelters along the island platforms.