WNT9B

WNT9B
Identifiers
Aliases	WNT9B, WNT14B, WNT15, Wnt family member 9B
External IDs	OMIM: 602864; MGI: 1197020; HomoloGene: 2551; GeneCards: WNT9B; OMA:WNT9B - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.32 Start 46,833,201 bp[1] End 46,886,730 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 E1|11 67.47 cM Start 103,618,190 bp[2] End 103,640,647 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad duodenum human kidney prefrontal cortex placenta apex of heart superior frontal gyrus primary visual cortex right frontal lobe right auricle Top expressed in interventricular septum medullary collecting duct cortical collecting duct surface ectoderm labioscrotal swelling semi-lunar valve cloacal membrane lateral geniculate nucleus maxillary prominence mandibular prominence More reference expression data BioGPS n/a
Gene ontology Molecular function frizzled binding signaling receptor binding co-receptor binding receptor ligand activity Cellular component extracellular region extracellular space Biological process kidney morphogenesis cell-cell signaling cellular response to starvation mesonephric duct formation multicellular organism development male genitalia development cornea development in camera-type eye branching morphogenesis of an epithelial tube kidney rudiment formation collecting duct development regulation of asymmetric cell division embryonic cranial skeleton morphogenesis kidney development Wnt signaling pathway, planar cell polarity pathway cellular response to retinoic acid mesenchymal stem cell maintenance involved in nephron morphogenesis establishment of planar polarity involved in nephron morphogenesis nephron tubule morphogenesis roof of mouth development metanephric tubule development in utero embryonic development regulation of tube size mesonephric tubule development uterus morphogenesis response to retinoic acid regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis cell fate commitment branching involved in ureteric bud morphogenesis positive regulation of catalytic activity metanephric tubule formation regulation of protein phosphorylation negative regulation of stem cell population maintenance midbrain dopaminergic neuron differentiation non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Wnt signaling pathway neuron differentiation regulation of signaling receptor activity canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7484 22412 Ensembl ENSG00000158955 ENSG00000276799 ENSMUSG00000018486 UniProt O14905 O35468 RefSeq (mRNA) NM_003396 NM_001320458 NM_011719 RefSeq (protein) NP_001307387 NP_003387 NP_035849 Location (UCSC) Chr 17: 46.83 – 46.89 Mb Chr 11: 103.62 – 103.64 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein Wnt-9b (formerly Wnt15^[5]) is a protein that in humans is encoded by the WNT9B gene.^[6]

The Wnt family of genes produce glycolipoproteins that are involved with signaling and developmental processes. Like other Wnt genes, Wnt-9b codes for the Wnt-9b protein which participates in the canonical Wnt/β-catenin signaling pathway. Wnt-9b is a gene found on chromosome 17 in region 17q21. It can be traced to function in the establishment of the kidneys, because Wnt9 is critical for morphogenesis of the nephron.^[7] This gene can impact kidney function in more than one way. Improper expression of the gene can cause cyst development on the kidney tubules, and in mice, mutant Wnt9 genes that cause lower protein concentrations resulted in failure of the kidneys to thrive shortly after birth.^[8] Wnt-9b is a gene that often expressed in the epithelial cells of the Wolfian duct in early male and female embryos. In the embryos, Wnt11 is expressed at the branching points of the kidney tubules while Wnt-9b is expressed in a higher concentration at the stalk of the tubules.^[9] Wnt-9b has also been tied to the involvement of neural differentiation by induction of retinoic acid, according to the NCBI.^[10]

References

1. ENSG00000276799 GRCh38: Ensembl release 89: ENSG00000158955, ENSG00000276799 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018486 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Garriock RJ, Warkman AS, Meadows SM, D'Agostino S, Krieg PA (2007). "Census of vertebrate Wnt genes: isolation and developmental expression of Xenopus Wnt2, Wnt3, Wnt9a, Wnt9b, Wnt10a, and Wnt16". Developmental Dynamics. 236 (5): 1249–58. doi:10.1002/dvdy.21156. PMID 17436276. S2CID 21016668.
6. "Entrez Gene: Wnt9b wingless-type MMTV integration site family, member 9B".
7. Karner C, Chirumamilla R, Aoki S, et al. (2009). "Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis". Nat Genet. 41 (7): 793–799. doi:10.1038/ng.400. PMC 2761080. PMID 19543268.
8. Karner C, Chirumamilla R, Aoki S, et al. (2009). "Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis". Nat Genet. 41 (7): 793–799. doi:10.1038/ng.400. PMC 2761080. PMID 19543268.
9. Carroll T, Park J, Hayashi S, Majumdar A, McMahon A, et al. (2005). "Wnt9b Plays a Central Role in the Regulation of Mesenchymal to Epithelial Transitions Underlying Organogenesis of the Mammalian Urogenital System". Developmental Cell. 9 (2): 283–292. doi:10.1016/j.devcel.2005.05.016. PMID 16054034.
10. "WNT9B Wnt family member 9B [Homo sapiens (human)]". NCBI Genes & Expression. 2021-04-06. Retrieved 2021-04-14.