WDR3

WDR3
Identifiers
Aliases	WDR3, DIP2, UTP12, WD repeat domain 3
External IDs	OMIM: 604737; MGI: 2443143; GeneCards: WDR3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	117,966,543 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	100,069,723 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; pancreatic ductal cell; ; buccal mucosa cell; ; parietal pleura; ; germinal epithelium; ; islet of Langerhans; ; visceral pleura; ; Epithelium of choroid plexus; ; epithelium of nasopharynx; ; hair follicle;
	Top expressed in
	primitive streak; ; medullary collecting duct; ; hand; ; condyle; ; epiblast; ; fossa; ; superior cervical ganglion; ; abdominal wall; ; renal corpuscle; ; hair follicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	snoRNA binding; RNA binding;
Cellular component	Pwp2p-containing subcomplex of 90S preribosome; small-subunit processome; nuclear membrane; nucleolus; nucleoplasm; nucleus;
Biological process	rRNA processing; maturation of SSU-rRNA;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10885
	269470
	ENSG00000065183
	ENSMUSG00000033285
	Q9UNX4
	Q8BHB4
	NM_006784
	NM_175552; NM_001355657
	NP_006775
	NP_780761; NP_001342586
	Wikidata
View/Edit Human	View/Edit Mouse

WD repeat-containing protein 3 is a protein that in humans is encoded by the WDR3 gene.^[5]^[6]

This gene encodes a nuclear protein containing 10 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, which usually include a trp-asp at the C-terminal end. Proteins belonging to the WD repeat family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000065183 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033285 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Claudio JO, Liew CC, Ma J, Heng HH, Stewart AK, Hawley RG (Aug 1999). "Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13". Genomics. 59 (1): 85–9. doi:10.1006/geno.1999.5858. PMID 10395803.
^ ^a ^b "Entrez Gene: WDR3 WD repeat domain 3".

Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Claudio JO, Liew CC, Dempsey AA, et al. (1999). "Identification of sequence-tagged transcripts differentially expressed within the human hematopoietic hierarchy". Genomics. 50 (1): 44–52. doi:10.1006/geno.1998.5308. PMID 9628821.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000065183 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033285 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10395803-5] Claudio JO, Liew CC, Ma J, Heng HH, Stewart AK, Hawley RG (Aug 1999). "Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13". Genomics. 59 (1): 85–9. doi:10.1006/geno.1999.5858. PMID 10395803.

[entrez-6] "Entrez Gene: WDR3 WD repeat domain 3".

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WDR3

References

Further reading

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