Keilis-Borok was born in Moscow, Soviet Union. His father, Isaak Moiseevich Keilis, was a jeweler. His mother, Ksenia Ruvimovna Borok, was from Lithuania. Both were Jewish.[2]
He was also a member of: Committee for International Security and Disarmament, Russian Academy of Sciences (1998–2000); The Union's Scientific Committee for the UN Decade for Natural Disasters Reduction (1990–1999); International Working Group on the Geological Safety of Nuclear Waste Depositories (1994–1997).
He was awarded the First Lewis Fry Richardson Medal for exceptional contributions to non-linear geophysics (1998), a Doctor Honoris Causa, Institut de Physique du Globe, Paris, and the 21st Century Collaborative Activity Award for Studying Complex Systems, McDonnell Foundation.
His team of researchers used new algorithmic methods for earthquake prediction. Keilis-Borok's method has been retroactively applied to 31 cases dating back to 1989, with correlation 25 times (not including two near misses), including the Samoa area quake (September, 2009) and the Sumatra quake (September, 2009).
In response to his prediction of an earthquake in California in 2005, US Geological Survey has said: "The work of the Keilis-Borok team is a legitimate approach to earthquake prediction research. However, the method is unproven, and it will take much additional study, and many additional trial predictions, before it can be shown whether it works, and how well."[4][5] The California Earthquake Prediction Evaluation Council determined, "To date there is no evidence that these, or related methods, yield useful intermediate term forecasts."[6] No earthquake occurred in the predicted location or time period.
Keilis-Borok, in collaboration with Allan Lichtman, used some of his techniques to create The Keys to the White House, a presidential election prediction system. It has accurately predicted every United States presidential election since 1984, with the exception of the 2024 election and 2000 election.[7]