User:MiltonRex

KIAA0895 is a human gene that codes for a protein known as KIAA0895 protein or hypothetical protein LOC23366.^[1] Other known aliases are OTTHUMP00000206979 and OTTHUMP00000206980.^[2]

The KIAA0895 gene is located at p14.2 on chromosome 7.

It can be transcribed into 15 different transcript variants, which in turn can produce 13 different isoforms of the protein.^[3]

The genomic DNA is 65,976 [base pair]s long ^[1], while the longest mRNA that it produces is 4463 bases long.

KIAA0895 is surrounded by the following genes on chromosome 7 ^[1]:

• ELMO1
• AOAH
• HERPUD2
• TBX20

The longest protein isoform that is produced by the KIAA0895 gene is termed LOC23366 isoform 1 and is 520 amino acids long^[4].

LOC23366 contains a domain of unknown function called DUF 1704 ^[5].

It also contains a region of low complexity from position 120 to position 150 in the protein^[6], and an arginine-rich area from position 12 to position 51^[7].

The KIAA0895 protein is predicted to undergo phosphorylation at several serines, threonines, and tyrosines throughout it's structure, particularly in the first half of the protein^[8] The predicted phosphorylation sites are shown on the accompanying graph. There are also predicted to be three N-linked glycosylation sites^[9].

KIAA0895 is shown to be expressed at low levels in various tissues throughout the body. It is expressed most highly in the adrenal gland, the bone marrow, and the testis.^[10]. It is also found in cancerous tissues, most highly in cervical tumors and bladder carcinoma.

KIAA0895 has one paralog in humans known as KIAA0895L ^[11]. Orthologs have been found in all mammals, and eukaryotes through T. thermophila^[12]. The full list of organisms in which orthologs have been found is given below.

Category:Human proteins