User:Akalsip/sandbox
BOP (benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate) reagent is a reagent commonly used in the synthesis of peptides. Its use is discour
BOP (benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate) reagent is a reagent commonly used in the synthesis of peptides. Its use is discouraged because coupling using BOP liberates HMPA which is carcinogenic, although for small scale use in an organic laboratory this is not a great disadvantage as it is in large scale industrial usage.
BOP has been used for peptide coupling, synthesis of esters, esterification of carboxylic acids, or as a catalyst.[1][2][unreliable source?] This reagent is advantageous in peptide coupling to other derived reagents because there are no side reactions from the dehydration of asparagine or glutamine.[2] In peptide coupling the BOP reagent works well because it forms reactive intermediates which allow for the amines to bond together with little energy loss.[3] In the reduction of carboxylic acids using the BOP reagent with NaBH4 resulted in high percent yields. [3].
 | This is a user sandbox of Akalsip. You can use it for testing or practicing edits. This is not the place where you work on your assigned article for a dashboard.wikiedu.org course. Visit your Dashboard course page and follow the links for your assigned article in the My Articles section. |
- ^ "(Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 226084". BOP Reagent. Retrieved 2020-02-11.
- ^ a b Prasad, KVSRG; Bharathi, K; Haseena, Banu B (5 January 2011). "Applications of Peptide Coupling Reagents- An Update". International Journal of Pharmaceutical Sciences Review and Research. 8 (1): 108–119 – via Global Research.
- ^ a b McGeary, Ross P. (1998-05-14). "Facile and chemoselective reduction of carboxylic acids to alcohols using BOP reagent and sodium borohydride". Tetrahedron Letters. 39 (20): 3319–3322. doi:10.1016/S0040-4039(98)00480-8. ISSN 0040-4039.
Content Disclaimer
Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.
- The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
- There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
- It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
- Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
- Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.