Threshold of toxilogical concern

The threshold of toxilogical concern (or TTC) is a method for determining the level of exposure to chemicals above which would be considered toxic,^[1] in cases where data about such chemicals is scarce or non-existent.^{[2][3][4][5][6]}

References

1. Kroes, R.; Kleiner, J.; Renwick, A. (August 2005). "The threshold of toxicological concern concept in risk assessment". Toxicological Sciences. 86 (2): 226–230. doi:10.1093/toxsci/kfi169. ISSN 1096-6080. PMID 15829616.
2. Abstract Archived 2023-07-10 at the Wayback Machine jhsph.edu
3. Threshold of Toxicological Concern Archived 2023-12-03 at the Wayback Machine American Chemistry
4. Serafimova, Rositsa; Coja, Tamara; Kass, George E. N. (2021). "Application of the Threshold of Toxicological Concern (TTC) in Food Safety: Challenges and Opportunities". Frontiers in Toxicology. 3: 655951. doi:10.3389/ftox.2021.655951. ISSN 2673-3080. PMC 8915901. PMID 35295160.
5. Development, Office of Research &. "Derivation of New Threshold of Toxicological Concern Values for Exposure via Inhalation for Environmentally-Relevant Chemicals". cfpub.epa.gov. Archived from the original on 2023-07-10. Retrieved 2023-07-10.
6. Najjar, Abdulkarim; Ellison, Corie A.; Gregoire, Sebastien; Hewitt, Nicola J. (2023-01-01). "Practical application of the interim internal threshold of toxicological concern (iTTC): a case study based on clinical data". Archives of Toxicology. 97 (1): 155–164. Bibcode:2023ArTox..97..155N. doi:10.1007/s00204-022-03371-6. ISSN 1432-0738. PMC 9816204. PMID 36149470.