Tersolisib

Tersolisib

Tersolisib

Tersolisib
Clinical data
Other namesLY4064809
Identifiers
  • 1-(2-aminopyrimidin-5-yl)-3-[(1R)-1-(5,7-difluoro-3-methyl-1-benzofuran-2-yl)-2,2,2-trifluoroethyl]urea
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
PDB ligand
Chemical and physical data
FormulaC16H12F5N5O2
Molar mass401.297 g·mol−1
3D model (JSmol)
  • CC1=C(OC2=C1C=C(C=C2F)F)[C@H](C(F)(F)F)NC(=O)NC3=CN=C(N=C3)N
  • InChI=InChI=1S/C16H12F5N5O2/c1-6-9-2-7(17)3-10(18)12(9)28-11(6)13(16(19,20)21)26-15(27)25-8-4-23-14(22)24-5-8/h2-5,13H,1H3,(H2,22,23,24)(H2,25,26,27)/t13-/m1/s1
  • Key:LGPNQALKGDDVBD-CYBMUJFWSA-N

Tersolisib is an investigational new drug that is being evaluated by Eli Lilly and Company for the treatment of solid tumors. It is a PI3Kα inhibitor.[1][2]

References

  1. ^ "Tersolisib - Eli Lilly and Company". AdisInsight. Springer Nature Switzerland AG.
  2. ^ Schmitz AE, Udgata S, Johnson KA, Deming DA (May 2025). "The Precision-Guided Use of PI3K Pathway Inhibitors for the Treatment of Solid Malignancies". Biomedicines. 13 (6): 1319. doi:10.3390/biomedicines13061319. PMC 12189650. PMID 40564038.
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