Tariquidar

Tariquidar

Clinical data
ATC code	none
Identifiers
IUPAC name N-[2-[[4-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide
CAS Number	206873-63-4^Y
PubChem CID	148201
ChemSpider	130650^N
UNII	J58862DTVD
ChEMBL	ChEMBL348475^N
CompTox Dashboard (EPA)	DTXSID10174746
Chemical and physical data
Formula	C38H38N4O6
Molar mass	646.744 g·mol^−1
3D model (JSmol)	Interactive image
SMILES COC1=C(C=C2CN(CCC2=C1)CCC3=CC=C(C=C3)NC(=O)C4=CC(=C(C=C4NC(=O)C5=CC6=CC=CC=C6N=C5)OC)OC)OC
InChI InChI=1S/C38H38N4O6/c1-45-33-18-25-14-16-42(23-28(25)19-34(33)46-2)15-13-24-9-11-29(12-10-24)40-38(44)30-20-35(47-3)36(48-4)21-32(30)41-37(43)27-17-26-7-5-6-8-31(26)39-22-27/h5-12,17-22H,13-16,23H2,1-4H3,(H,40,44)(H,41,43)^N Key:LGGHDPFKSSRQNS-UHFFFAOYSA-N^N
^NY (what is this?)  (verify)

Tariquidar (INN/USAN) is a P-glycoprotein inhibitor^[1] undergoing research as an adjuvant against multidrug resistance in cancer.

References

1. Robey RW, Shukla S, Finley EM, Oldham RK, Barnett D, Ambudkar SV, Fojo T, Bates SE (March 2008). "Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1((R))". Biochemical Pharmacology. 75 (6): 1302–12. doi:10.1016/j.bcp.2007.12.001. PMC 2346578. PMID 18234154.