On 28 January 2022, Uwakwe joined EFL League One side Crewe Alexandra on an 18-month contract,[9][10] and made his debut in Crewe's 1–0 league defeat at Gillingham on 1 February 2022.[11] On his fifth appearance for Crewe, against Oxford United, he suffered a knee injury, ruling him out for several weeks.[12] He scored his first (and only) Crewe goal in a 2-2 draw at Harrogate Town on 18 February 2023.[13] At the end of the season, he was offered a new contract by the club,[14] but on 30 June 2023, it was announced he was leaving Crewe by mutual consent.[15]