TXK (gene)

TXK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DM0
Identifiers
Aliases	TXK, BTKL, PSCTK5, PTK4, RLK, TKL, TXK tyrosine kinase
External IDs	OMIM: 600058; MGI: 102960; HomoloGene: 2497; GeneCards: TXK; OMA:TXK - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p12 Start 48,066,393 bp[1] End 48,134,250 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 C3.2|5 38.44 cM Start 72,853,321 bp[2] End 72,910,120 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood testicle spleen lymph node appendix right uterine tube bone marrow cells right lobe of liver upper lobe of left lung Top expressed in thymus blood lymph node morula pharynx mesenteric lymph nodes spleen subcutaneous adipose tissue granulocyte ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding DNA binding protein kinase activity DNA-binding transcription activator activity, RNA polymerase II-specific kinase activity RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding protein tyrosine kinase activity signaling receptor binding ATP binding non-membrane spanning protein tyrosine kinase activity Cellular component cytoplasm membrane extrinsic component of cytoplasmic side of plasma membrane plasma membrane nucleus Biological process cell differentiation regulation of transcription, DNA-templated adaptive immune response phosphorylation tissue regeneration transmembrane receptor protein tyrosine kinase signaling pathway immune system process regulation of transcription by RNA polymerase II cytokine production positive regulation of interferon-gamma-mediated signaling pathway positive regulation of interferon-gamma production activation of phospholipase C activity transcription, DNA-templated protein phosphorylation regulation of cell population proliferation peptidyl-tyrosine autophosphorylation integrin-mediated signaling pathway protein autophosphorylation regulation of platelet activation T cell receptor signaling pathway positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7294 22165 Ensembl ENSG00000074966 ENSMUSG00000054892 UniProt P42681 P42682 RefSeq (mRNA) NM_003328 NM_001122754 NM_001289494 NM_001289495 NM_013698 RefSeq (protein) NP_003319 NP_001116226 NP_001276423 NP_001276424 NP_038726 Location (UCSC) Chr 4: 48.07 – 48.13 Mb Chr 5: 72.85 – 72.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tyrosine-protein kinase TXK is an enzyme that in humans is encoded by the TXK gene.^[5][6][7]

References

1. GRCh38: Ensembl release 89: ENSG00000074966 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000054892 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Haire RN, Ohta Y, Lewis JE, Fu SM, Kroisel P, Litman GW (Nov 1994). "TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12". Hum Mol Genet. 3 (6): 897–901. doi:10.1093/hmg/3.6.897. PMID 7951233.
6. Spritz RA, Strunk KM, Lee ST, Lu-Kuo JM, Ward DC, Le Paslier D, Altherr MR, Dorman TE, Moir DT (Jan 1995). "A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12". Genomics. 22 (2): 431–6. doi:10.1006/geno.1994.1405. PMID 7528718.
7. "Entrez Gene: TXK TXK tyrosine kinase".

Further reading

• Suzuki N, Nara K, Suzuki T (2006). "Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease". Clinical Medicine & Research. 4 (2): 147–51. doi:10.3121/cmr.4.2.147. PMC 1483892. PMID 16809408.
• Ohta Y, Haire RN, Amemiya CT, et al. (1996). "Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene". Oncogene. 12 (4): 937–42. PMID 8632917.
• Wardenburg JB, Fu C, Jackman JK, et al. (1996). "Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function". J. Biol. Chem. 271 (33): 19641–4. doi:10.1074/jbc.271.33.19641. PMID 8702662.
• Raab M, da Silva AJ, Findell PR, Rudd CE (1997). "Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2". Immunity. 6 (2): 155–64. doi:10.1016/S1074-7613(00)80422-7. PMID 9047237.
• Schneider H, Schwartzberg PL, Rudd CE (1998). "Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4". Biochem. Biophys. Res. Commun. 252 (1): 14–9. doi:10.1006/bbrc.1998.9559. PMID 9813138.
• Rajagopal K, Sommers CL, Decker DC, et al. (2000). "RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation". J. Exp. Med. 190 (11): 1657–68. doi:10.1084/jem.190.11.1657. PMC 2195727. PMID 10587356.
• Schneider H, Guerette B, Guntermann C, Rudd CE (2000). "Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells". J. Biol. Chem. 275 (6): 3835–40. doi:10.1074/jbc.275.6.3835. PMID 10660534.
• Chamorro M, Czar MJ, Debnath J, et al. (2004). "Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk". BMC Immunol. 2: 3. doi:10.1186/1471-2172-2-3. PMC 31577. PMID 11353545.
• Takeba Y, Nagafuchi H, Takeno M, et al. (2002). "Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription". J. Immunol. 168 (5): 2365–70. doi:10.4049/jimmunol.168.5.2365. PMID 11859127.
• Kashiwakura J, Suzuki N, Takeno M, et al. (2002). "Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site". Biol. Pharm. Bull. 25 (6): 718–21. doi:10.1248/bpb.25.718. PMID 12081135.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Rafalska I, Zhang Z, Benderska N, et al. (2005). "The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation". Hum. Mol. Genet. 13 (15): 1535–49. doi:10.1093/hmg/ddh167. PMID 15175272.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.