TRIM6

TRIM6
Identifiers
Aliases	TRIM6, RNF89, tripartite motif containing 6
External IDs	OMIM: 607564; MGI: 2137352; GeneCards: TRIM6
Enzyme activity
Gene location (Human)
Chr.	Chromosome 11 (human)
End	5,612,958 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	103,884,359 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; gonad; ; human kidney; ; parotid gland; ; palpebral conjunctiva; ; germinal epithelium; ; tibia; ; testicle; ; parietal pleura;
	Top expressed in
	yolk sac; ; morula; ; blastocyst; ; embryo; ; epiblast; ; primitive streak; ; spermatocyte; ; embryo; ; tail of embryo; ; secondary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein-macromolecule adaptor activity; protein tyrosine kinase binding; ubiquitin protein ligase activity; zinc ion binding; transcription factor binding; metal ion binding; protein binding; protein kinase binding; transferase activity;
Cellular component	cytoplasm; cytosol; intracellular anatomical structure; nucleus;
Biological process	positive regulation of transcription regulatory region DNA binding; cellular response to virus; positive regulation of type I interferon-mediated signaling pathway; regulation of NIK/NF-kappaB signaling; free ubiquitin chain polymerization; cellular response to interferon-beta; protein trimerization; protein polyubiquitination; negative regulation of gene expression; positive regulation of peptidyl-serine phosphorylation; negative regulation of stem cell differentiation; response to lipopolysaccharide; negative regulation of viral genome replication; positive regulation of gene expression; positive regulation of peptidyl-threonine phosphorylation; protein ubiquitination; negative regulation of transcription, DNA-templated; positive regulation of defense response to virus by host; viral process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	117854
	94088
	ENSG00000121236
	ENSMUSG00000072244
	Q9C030
	Q8BGE7
	NM_058166; NM_001003818; NM_001198644; NM_001198645
	NM_001013616
	NP_001003818; NP_001185573; NP_001185574; NP_477514
	NP_001013637
	Wikidata
View/Edit Human	View/Edit Mouse

Tripartite motif-containing protein 6 is a protein that in humans is encoded by the TRIM6 gene.^[5]^[6]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.

The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. A read-through transcript transcribed from this gene and TRIM34 has been observed.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000121236 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000072244 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
^ ^a ^b "Entrez Gene: TRIM6 tripartite motif-containing 6".

Li X, Gold B, O'hUigin C, et al. (2007). "Unique features of TRIM5alpha among closely related human TRIM family members". Virology. 360 (2): 419–33. doi:10.1016/j.virol.2006.10.035. PMID 17156811.
Zhang F, Hatziioannou T, Perez-Caballero D, et al. (2006). "Antiretroviral potential of human tripartite motif-5 and related proteins". Virology. 353 (2): 396–409. doi:10.1016/j.virol.2006.05.035. PMID 16828831.
Li X, Li Y, Stremlau M, et al. (2006). "Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains". J. Virol. 80 (13): 6198–206. doi:10.1128/JVI.00283-06. PMC 1488960. PMID 16775307.
Woo JS, Imm JH, Min CK, et al. (2006). "Structural and functional insights into the B30.2/SPRY domain". EMBO J. 25 (6): 1353–63. doi:10.1038/sj.emboj.7600994. PMC 1422157. PMID 16498413.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Orimo A, Tominaga N, Yoshimura K, et al. (2001). "Molecular cloning of ring finger protein 21 (RNF21)/interferon-responsive finger protein (ifp1), which possesses two RING-B box-coiled coil domains in tandem". Genomics. 69 (1): 143–9. doi:10.1006/geno.2000.6318. PMID 11013086.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000121236 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000072244 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11331580-5] Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.

[entrez-6] "Entrez Gene: TRIM6 tripartite motif-containing 6".

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[3]

[4]

[5]

[6]

TRIM6

References

Further reading

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