TNIP1

10318

TNIP1
TNIP1
Identifiers
AliasesTNIP1, ABIN-1, NAF1, VAN, nip40-1, TNFAIP3 interacting protein 1
External IDsOMIM: 607714; MGI: 1926194; GeneCards: TNIP1
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

10318

57783

Ensembl

ENSG00000145901

ENSMUSG00000020400

UniProt

Q15025

Q9WUU8

RefSeq (mRNA)

NM_001199275
NM_001199276
NM_001271455
NM_001271456
NM_021327

RefSeq (protein)

NP_001186204
NP_001186205
NP_001258384
NP_001258385
NP_067302

Location (UCSC)Chr 5: 151.03 – 151.09 MbChr 11: 54.8 – 54.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TNFAIP3-interacting protein 1, also known as ABIN-1, is a protein that in humans is encoded by the TNIP1 gene.[5][6][7]

Association with autoimmune diseases

Genetic variations within the region of the TNIP1 gene have been shown to have association with several autoimmune diseases:

TNIP1 dysfunction or deficiency contributes to hyperinflammarion and may predispose healthy cells to the inflammatory response to otherwise innocuous TLR ligand exposure.[15]

Association with neurodegenerative diseases

A recent genome-wide association study (GWAS) has found that genetic variations in TNIP1 are associated with late-onset sporadic Alzheimer's disease (LOAD).[16]

Interactions

TNIP1 contains multiple amino acid sites that are phosphorylated and ubiquitinated,[17] and has been shown to interact with TNFAIP3,[18] MAP3K1,[19] and MAPK1.[20]

Regulation

TNIP1 was shown to be part of a transcription module controlled by BCL3. BCL3 gen was found to be strongly associated with Aβ42 after conditioning for APOE and was found as upregulated in the brain of patients with LOAD.[16]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145901 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020400 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fukushi M, Dixon J, Kimura T, Tsurutani N, Dixon MJ, Yamamoto N (January 1999). "Identification and cloning of a novel cellular protein Naf1, Nef-associated factor 1, that increases cell surface CD4 expression". FEBS Letters. 442 (1): 83–88. doi:10.1016/S0014-5793(98)01631-7. PMID 9923610. S2CID 86298611.
  6. ^ Gupta K, Ott D, Hope TJ, Siliciano RF, Boeke JD (December 2000). "A human nuclear shuttling protein that interacts with human immunodeficiency virus type 1 matrix is packaged into virions". Journal of Virology. 74 (24): 11811–11824. doi:10.1128/JVI.74.24.11811-11824.2000. PMC 112464. PMID 11090181.
  7. ^ "Entrez Gene: TNIP1 TNFAIP3 interacting protein 1".
  8. ^ Allanore Y, Saad M, Dieudé P, Avouac J, Distler JH, Amouyel P, et al. (July 2011). "Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis". PLOS Genetics. 7 (7) e1002091. doi:10.1371/journal.pgen.1002091. PMC 3131285. PMID 21750679.
  9. ^ Nair RP, Duffin KC, Helms C, Ding J, Stuart PE, Goldgar D, et al. (February 2009). "Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways". Nature Genetics. 41 (2): 199–204. doi:10.1038/ng.311. PMC 2745122. PMID 19169254.
  10. ^ Bowes J, Orozco G, Flynn E, Ho P, Brier R, Marzo-Ortega H, et al. (September 2011). "Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis". Annals of the Rheumatic Diseases. 70 (9): 1641–1644. doi:10.1136/ard.2011.150102. PMC 3147229. PMID 21623003.
  11. ^ Gateva V, Sandling JK, Hom G, Taylor KE, Chung SA, Sun X, et al. (November 2009). "A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus". Nature Genetics. 41 (11): 1228–1233. doi:10.1038/ng.468. PMC 2925843. PMID 19838195.
  12. ^ Han JW, Zheng HF, Cui Y, Sun LD, Ye DQ, Hu Z, et al. (November 2009). "Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus". Nature Genetics. 41 (11): 1234–1237. doi:10.1038/ng.472. PMID 19838193. S2CID 205356205.
  13. ^ Oka S, Higuchi T, Furukawa H, Nakamura M, Komori A, Abiru S, et al. (June 2018). "Association of a single nucleotide polymorphism in TNIP1 with type-1 autoimmune hepatitis in the Japanese population". Journal of Human Genetics. 63 (6): 739–744. doi:10.1038/s10038-018-0440-0. PMID 29559739. S2CID 4477603.
  14. ^ Brady MP, Korte EA, Caster DJ, Powell DW (October 2020). "TNIP1/ABIN1 and lupus nephritis: review". Lupus Science & Medicine. 7 (1) e000437. doi:10.1136/lupus-2020-000437. PMC 7597513. PMID 33122334.
  15. ^ Shamilov R, Aneskievich BJ (2018-10-03). "TNIP1 in Autoimmune Diseases: Regulation of Toll-like Receptor Signaling". Journal of Immunology Research. 2018 3491269. doi:10.1155/2018/3491269. PMC 6192141. PMID 30402506.
  16. ^ a b Wightman DP, Jansen IE, Savage JE, Shadrin AA, Bahrami S, Holland D, et al. (September 2021). "A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease". Nature Genetics. 53 (9): 1276–1282. doi:10.1038/s41588-021-00921-z. hdl:1871.1/61f01aa9-6dc7-4213-be2a-d3fe622db488. ISSN 1061-4036. PMC 10243600. PMID 34493870. S2CID 237442349.
  17. ^ "TNIP1 (human)". www.phosphosite.org. Retrieved 2020-10-31.
  18. ^ Heyninck K, De Valck D, Vanden Berghe W, Van Criekinge W, Contreras R, Fiers W, et al. (June 1999). "The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN". The Journal of Cell Biology. 145 (7): 1471–1482. doi:10.1083/jcb.145.7.1471. PMC 2133159. PMID 10385526.
  19. ^ Charlaftis N, Suddason T, Wu X, Anwar S, Karin M, Gallagher E (November 2014). "The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines". The EMBO Journal. 33 (21): 2581–2596. doi:10.15252/embj.201488351. PMC 4282369. PMID 25260751.
  20. ^ Zhang S, Fukushi M, Hashimoto S, Gao C, Huang L, Fukuyo Y, et al. (September 2002). "A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling". Biochemical and Biophysical Research Communications. 297 (1): 17–23. doi:10.1016/S0006-291X(02)02086-7. PMID 12220502.

Further reading

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.