The molecule is tetrahedral with C2vsymmetry. The S-O distance is 140.5 pm, S-F is 153.0 pm. As predicted by VSEPR, the O-S-O angle is more open than the F-S-F angle, 124° and 97°, respectively.[3]
One synthesis begins with the preparation of potassium fluorosulfite:[4]
On a laboratory scale, sulfuryl fluoride has been conveniently prepared from 1,1'-sulfonyldiimidazole, in the presence of potassium fluoride and acid.[6][7]
Sulfuryl fluoride is unreactive toward molten sodium metal.[3] Similarly it is slow to hydrolyze, but eventually converts to sulfur trioxide.[8][9]
Originally developed by the Dow Chemical Company, sulfuryl fluoride is in widespread use as a structural fumigantinsecticide to control drywood termites, particularly in warm-weather portions of the southwestern and southeastern United States and in Hawaii. Less commonly, it can also be used to control rodents, powderpost beetles, deathwatch beetles, bark beetles, and bedbugs. Its use has increased as a replacement for methyl bromide, which was phased out because of harm to the ozone layer. It is an alternative to the use of phosphine, which is acutely toxic.[11]
Fumigation methodology
During application, the building is enclosed and filled with the gas for a period of time, usually at least 16–18 hours, sometimes as long as 72 hours. The building must then be ventilated, generally for at least 6 hours, before occupants can return. California regulations are such that the tent will be on for three to five days, which includes ventilation. In the US, sulfuryl fluoride must be transported in a vehicle marked with "Inhalation Hazard 2" placards.[12][13] Most states require a license or certification for the individual applying the fumigant.
The concentration is continuously monitored and maintained at the specified level using electronic equipment. Possible leakages are also checked by low range electronic detectors. Reentry to the home is allowed when the concentration level is at or below 5 ppm.[14] Sulfuryl fluoride is colorless and odorless, however, during the fumigation process, a warning agent called chloropicrin is first released into the building to ensure that no occupants remain. Tent fumigation is the most effective treatment for the extermination of known and unknown infestations of wood-destroying insects. Heat is the only other approved method for whole structure treatment for termites in California.[15] Sulfuryl fluoride provides no protection from future infestations, although heavy re-infestation can take several years since drywood termites have slower growing colonies than ground termites.
U.S. perspective
Sulfuryl fluoride is marketed in the U.S. by three manufacturers, under four different brand names. Vikane (Dow) (EPA Reg. No. 62719- 4-ZA) has been commercially available since the early 1960s, with Zythor (marketed by competitor Ensystex of North Carolina) (EPA Reg. No. 81824- 1-AA) being more recently introduced gradually as its use is approved by individual states (in Florida circa 2004, but not in California until October 2006, for example). Sulfuryl fluoride has been marketed as a post-harvest fumigant for dry fruits, nuts, and grains under the trade name ProFume (U.S. EPA Reg. No. 62719- 376-AA).[16] Most recently Drexel Chemical Company has registered Master Fume (EPA Reg. No. 19713-596-AA) for the structural market, competing against Vikane and Zythor.[17]
Health hazards
Inhalation of sulfuryl fluoride is hazardous and may result in respiratory irritation, pulmonary edema, nausea, abdominal pain, central nervous system depression, numbness in the extremities, muscle twitching, seizures, and death.[18][19][20] These high exposures occurred when people entered into structures illegally during fumigation or after insufficient aeration. Epidemiological studies showed that fumigation workers who used sulfuryl fluoride showed neurological effects, which included reduced performance on cognitive tests and pattern memory tests, and reduced olfactory function.[21]
Case studies
In 1987, an elderly couple was exposed to sulfuryl fluoride in their house already cleared for reentry.[21] While the fumigation company opened windows and doors, and aerated the house with fans, sulfuryl fluoride level was not measured. It was not detected when the air was sampled 12 days after aeration. The couple experienced weakness, nausea and shortness of breath that evening. The man suffered a seizure and died the following day. His wife's condition got worse with pulmonary edema, and she died after a cardiovascular arrest 6 days later.
In 2015, a 10-year-old boy suffered severe brain damage and lost function of his left arm and leg after his home was treated with sulfuryl fluoride and insufficiently aerated, prompting a criminal investigation by the Department of Justice and the Florida Department of Agricultural and Consumer Services.[22] Two pest control workers later pled guilty to charges of misuse of the pesticide resulting in the boy's poisoning, and were each sentenced to one year in prison.[23]
In 2016, a 24-year-old man who allegedly entered an apartment that was being fumigated in Fremont, California to commit a burglary was exposed to sulfuryl fluoride and chloropicrin and died shortly thereafter. According to a police officer, he experienced labored breathing and was sweating before he collapsed just a few steps from the first floor window of the apartment he allegedly burglarized.[24]
Sulfuryl fluoride (SO2F2) measured by the Advanced Global Atmospheric Gases Experiment (AGAGE) in the lower atmosphere (troposphere) at stations around the world. Abundances are given as pollution free monthly mean mole fractions in parts-per-trillion.Sulfuryl fluoride timeseries at various latitudes.
Based on the first high frequency, high precision, in situ atmospheric and archived air measurements, sulfuryl fluoride has an atmospheric lifetime of 30–40 years,[8] much longer than the 5 years earlier estimated.[25]
Sulfuryl fluoride has been reported to be a greenhouse gas which is about 4000–5000 times more efficient in trapping infrared radiation (per kg) than carbon dioxide (per kg).[8][26][27] The amount of sulfuryl fluoride released into the atmosphere is about 2000 metric tons per year.[8] The most important loss process of sulfuryl fluoride is dissolution of atmospheric sulfuryl fluoride in the ocean followed by hydrolysis.
^Ganim S (5 September 2015). "10-year-old hospitalized after termite fumigation". Cable News Network (CNN). Retrieved 5 September 2015. Sulfuryl fluoride, a gas fumigant, was the pesticide used to fumigate, sources told CNN.
^KEMI, SULFURYL FLUORIDE (PT8), Competent Authority Report, Document III-A7, Ecotoxicological Profile Including Environmental Fate and Behaviour, Swedish Chemicals Agency, Sweden, 2005.
^Papadimitriou, V.C., R.W. Portmann, D.W. Fahey, J. Mühle, R.F. Weiss, and J.B. Burkholder, Experimental and Theoretical Study of the Atmospheric Chemistry and Global Warming Potential of SO2F2, Journal of Physical Chemistry A, 112 (49), 12657-12666, doi:10.1021/jp806368u, 2008.
^Sulbaek Andersen, M.P., D.R. Blake, F.S. Rowland, M.D. Hurley, and T.J. Wallington, Atmospheric Chemistry of Sulfuryl Fluoride: Reaction with OH Radicals, Cl Atoms and O3, Atmospheric Lifetime, IR Spectrum, and Global Warming Potential, Environmental Science & Technology, doi:10.1021/es802439f, 2009.
