Rosenberg was born in 1940, in the Bronx, the youngest of three children of Jewish immigrants from Poland,[2][1] who owned a luncheonette. He met his wife to be, Alice O’Connell during his residency at Boston’s Peter Bent Brigham Hospital, who was the chief nurse at the time. They got married in 1968 and have three daughters.[1]
Methodology
He is credited with developing the use of IL-2 and immune cells for the treatment of patients with melanoma in a procedure termed adoptive cell transfer.[3] He has shown that expanding immune cells (known as tumor infiltrating lymphocytes) in the lab can be used to treat patients with melanoma and has published two important studies describing their use. The first in 2002, demonstrated that some patients with advanced melanoma can be treated to complete remission with a combination of chemotherapy, immune cells and high doses of IL-2.[4] The second, in 2006, demonstrated that the receptor of T cells can be transferred to immune cells and in combination with chemotherapy and high doses of IL-2 can be used to treat patients with melanoma.[5] Although, this was the first time that the T cell receptor was used for gene therapy, it was not the first time that gene therapy was used in cancer. Tumor cells modified with a gene for immune growth factors such as GM-CSF, had been used many years previously and continue to be used, although the efficacy of GM-CSF modified tumor lines as a cancer vaccine remain extremely modest, at best.[6] There has been some debate as to the role of the T cells in treating the cancer in these studies as high-dose IL-2 and chemotherapy have also been shown to have anti-cancer properties. Nevertheless, the combination of chemotherapy, T cells and high-dose IL-2 was shown to be effective even in patients who had previously failed high-dose IL-2 treatment.
Rosenberg has pioneered the use of adoptive immunotherapy.
