The short opens on a small, worried group of Mexican mice thinking of how to get cheese from the AJAX cheese factory across the Mexico–United States border that is guarded by Sylvester. Sylvester has eaten any mice who have tried. The leader comes up with a brilliant idea: Gain the services of the aptly named "Speedy Gonzales". The group agrees, so the leader goes to the carnival where Speedy resides.
Speedy Gonzales is at the carnival attraction "Shoot Speedy" in which people try to shoot Speedy with bullets from a gun in order to "win a beeg prize." The leader tells Speedy, in Spanish, about the dire situation the mice are in, not having access to the cheese guarded by Sylvester. Speedy agrees to help and runs through the field between the mice and Sylvester to fetch an armful of cheese with each turn. After failing to catch Speedy by hand, Sylvester employs a hand net, mousetraps, landmines, baseball equipment, and a pipe to funnel Speedy right into his mouth, but Speedy manages to thwart him every time.
Finally getting fed up, Sylvester gets all the cheese from the factory, stacks it, and uses dynamite to blow it all up. However, all the cheese ends up raining down on the mice, causing Sylvester to cry and bang his head on an electric pole in vexation. Speedy ends the short by saying: "I like this pussycat fellow; he's silly!"
^Beck, Jerry (1991). I Tawt I Taw a Puddy Tat: Fifty Years of Sylvester and Tweety. New York: Henry Holt and Co. p. 129. ISBN0-8050-1644-9.
^Beck, Jerry; Friedwald, Will (1989). Looney Tunes and Merrie Melodies: A Complete Illustrated Guide to the Warner Bros. Cartoons. Henry Holt and Co. p. 277. ISBN0-8050-0894-2.
