Small nucleolar RNA snR54

Small nucleolar RNA snR54
Predicted secondary structure and sequence conservation of snosnR54
Identifiers
Symbol	snosnR54
Rfam	RF00473
Other data
RNA type	Gene; snRNA; snoRNA; CD-box
Domain(s)	Eukaryota
GO	GO:0006396 GO:0005730
SO	SO:0000593
PDB structures	PDBe

In molecular biology, snR54 is a non-coding RNA that is a member of the C/D class of snoRNA which contain the C box motif (UGAUGA) and D box motif (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. This snoRNA was first identified by a computational screen followed by experimental verification.^[1] This RNA guides the 2'-O-methylation of 18S rRNA. In yeast this snoRNA is found to reside in an intron of the IMD4 gene.

Species distribution

This snoRNA has been identified in both yeasts and Drosophila melanogaster.^[2]

References

1. Kiss T (April 2002). "Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions". Cell. 109 (2): 145–8. doi:10.1016/S0092-8674(02)00718-3. PMID 12007400. S2CID 8968788.
2. Lowe TM, Eddy SR (February 1999). "A computational screen for methylation guide snoRNAs in yeast". Science. 283 (5405): 1168–71. Bibcode:1999Sci...283.1168L. doi:10.1126/science.283.5405.1168. PMID 10024243.

External links

• Page for Small nucleolar RNA snR54 at Rfam
• Entry for snR54 in the UMASS Amherst Yeast snoRNA database