On October 14, 1986, a fire destroys an orphanage, killing many of the orphans and their matron Jene. Twenty years later, a high-rise apartment building stands on the site of the orphanage. In one of the apartment's penthouse suites resides Alex and her parents, Diana and Oscar.
For Alex's birthday, which happens to fall on the 20th anniversary of the fire, Diana and Oscar plan to throw a party and hires a group of party organizers. Upon arrival, the group led by Sonny consists of head caterer and chef Marge, the assistants Gino and Alyson and the magician/clown Jun, examines the building and begins to feel the presence of lost souls, starting with their elevator ride.
Upon stepping at Alex's suite, the group again experiences strange phenomena but dismisses them to set up for the party. After inviting some children with their matron, they begin Alex's birthday party. Unknown to any of them, the children and the matron they invited were the souls of the orphans and their matron who died in the fire.
The presence of the ghosts throws the party into chaos. The spirits manifest themselves altogether and the original 14th floor where the party was held is changed to 13. After a chase, the ghosts reappear in the form of the orphans and Jene, who reveals that Sonny and Jun are the only survivors of the fire and also caused it in an accident, with Alex being born on the ninth anniversary of the incident. The souls forgive the two and depart for the afterlife.
"Yaya"
Mischievous child prankster Benjo sends many nannies packing and resigning. When his mother Grace hires a new nanny named Cecil, Benjo promises to stop his mean pranks. Although things seem normal at first, Benjo becomes suspicious about Cecil; evidence is shown when the family's pet dog Toby barks mad at her on her arrival. Grace insisted for Benjo to calm down.
Benjo's suspicions arise and he becomes more watchful and alert. At school, a determined Benjo seeks help from his teacher Mel, telling him everything about Cecil's demonic nature. Mel reveals to Benjo that garlic is the only weapon to repel aswangs.
During the full moon, Cecil transforms into her aswang form, killing the house helper Hermie and the family driver Julio. Benjo takes his sister with him to run outside their house. Grace arrives with Mel before Cecil could catch the siblings. Recalling Mel's advice, Benjo fought the evil creature and thrusts garlic to Cecil's mouth, killing her instantly.
"LRT"
Thirteen commuters take the last trip of the Manila Light Rail Transit System Line 2 at nearly midnight from Katipunan to Santolan, supposedly. On board, Jean meets her long lost boyfriend Cesar. Jean introduces her son, Jimmy. During their conversation, a deacon named Lita preaches verses from the Bible, annoying some passengers.
The train travels into an abandoned station which the passengers assume to be the final stop. Exploring the station, they find out that everything is shut down and the gates are locked. After several minutes, the passengers decided to find a telephone booth to call for help. Actually, it was because while between Katipunan and Santolan, the train suddenly shook and went backward to the spur to Santolan Depot Workshops. They passed by some train cars in 2000 series under repair.
As they find a telephone, Martin is pulled up the balcony. The group finds his corpse and his heart pulled out. Unknown to them, a heart-eating eyeless, strong-sensed monster lurks the station every midnight. Lita also falls victim to the creature. Ojie, sees her corpse and is killed.
The creature kills more passengers until Steph, Don, Nina, Jimmy, Jean and Cesar are the only ones left. Nina is separated from the members. Nina and her boyfriend Rocky wander into an old train and discover corpses of previous victims. The monster appears behind Rocky and kills him while Nina escapes. Steph and Don escape the train after their friends Jenny and Rico were killed by the monster.
Steph and Don met with Jimmy, Jean and Caesar who were lost contact in the phone. The two friends go out to find an exit but are confronted and killed by the monster. After several desperate tries of finding an emergency exit, the remaining survivors Jean, Cesar and Jimmy, find an emergency exit. Shortly after climbing down from the station tower, Cesar pledges his still-living love for Jean. He urged Jimmy and Jean to run while he wards the monster off. After a long fight, Cesar is killed.
Jean and Jimmy find the police and tell everything what happened. The monster is then revealed to be the mutant son of their chief, and that the passengers on the last train every night are set up to be the food of the monster, with any survivors being killed off by the police. The police put Nina and Jimmy in their jail cell, just as the monster arrives while Nina, Jean, and Jimmy are about to scream. The janitors are then seen covering up the entire incident as the film ends.