Sertoli cell nodule

Sertoli cell nodule
Other names	Pick's adenoma, testicular tubular adenoma, tubular adenoma of the testis
Micrograph of a Sertoli cell nodule. H&E stain.
Specialty	Urology

A Sertoli cell nodule is a benign proliferation of Sertoli cells that arises in association with cryptorchidism (undescended testis).^[1] They are not composed of a clonal cell population, i.e. neoplastic; thus, technically, they should not be called an adenoma.^[2]

Pathology

Sertoli cell nodules are unencapsulated nodules that consist of:^[2][3][4]

1. cells arranged in well-formed tubules (that vaguely resemble immature Sertoli cells), with
2. bland hyperchromatic oval/round nuclei that are stratified, and
3. may contain eosinophilic (hyaline) blob in lumen (centre).

• 
  Micrograph of a Sertoli cell nodule. H&E stain.
• 
  Micrograph of a Sertoli cell nodule. H&E stain.

References

1. "Sertoli cell nodule". www.pathologyoutlines.com. Retrieved 2023-11-04.
2. Tadrous, Paul J. (2007). Diagnostic criteria handbook in histopathology: a surgical pathology vade mecum. John Wiley & Sons Canada. p. 227 =. ISBN 978-0-470-51903-5.
3. "Ashwagandha". 2018-09-24. Retrieved 19 November 2018.
4. Ricco R, Bufo P (October 1980). "[Histologic study of 3 cases of so-called tubular adenoma of the testis]". Boll. Soc. Ital. Biol. Sper. (in Italian). 56 (20): 2110–5. PMID 6109541.

Further reading

• Testis, Sex Cord Stromal Tumor - eMedicine.
• Govender, D.; Sing, Y.; Chetty, R. (2004). "Sertoli cell nodules in the undescended testis: A histochemical, immunohistochemical, and ultrastructural study of hyaline deposits". Journal of Clinical Pathology. 57 (8): 802–806. doi:10.1136/jcp.2004.015982. PMC 1770379. PMID 15280399.
• Barghorn, A.; Alioth, H-R; Hailemariam, S.; Bannwart, F.; Ulbright, T. M. (2006). "Giant Sertoli cell nodule of the testis: Distinction from other Sertoli cell lesions". Journal of Clinical Pathology. 59 (11): 1223–1225. doi:10.1136/jcp.2005.035253. PMC 1860496. PMID 17071812.