At the time of its formation, the ministry consisted of 22 ministers, eleven of whom were women, making it the first cabinet in Victoria's history to reach gender parity.[2] To accommodate this change Philip Dalidakis was removed from his cabinet position. However, his work as a minister was praised by Andrews.[3] Following the resignation of Gavin Jennings and the appointment of Ros Spence on 23 March 2020, the Cabinet became majority female.
On 26 September 2020, health minister Jenny Mikakos resigned as minister, following Premier Daniel Andrews stating in the board of inquiry into the hotel quarantine program that he regarded Mikakos "accountable" for the program.[12]Minister for Mental HealthMartin Foley was sworn in as the new health and ambulance services minister later that day.[13] A further reshuffle three days later on 29 September 2020 added Ingrid Stitt into the cabinet and the reassignment of some portfolios.[14]
On 16 December 2020, Jill Hennessy announced she would step down from the role of Attorney-General effective immediately to spend more time with her family but would stay in Parliament and recontest her seat at the 2022 election. She was replaced as Attorney-General by Jaclyn Symes. Mary-Anne Thomas was added to the cabinet and was appointed Minister for Regional Development and Minister for Agriculture.[15]
In February 2021, Lisa Neville was admitted to hospital and was forced to take leave due to Chron's disease. She returned to work in August 2021. The nature of her emergency services portfolio required regular travel to remote parts of the state at short notice, which was unsuitable for her medical condition. Therefore, Neville relinquished the portfolio to Attorney-General Jaclyn Symes.[16] Symes relinquished her resources portfolio to Jaala Pulford.[17]
On 11 October 2021, Luke Donnellan resigned as minister, following the first day of the IBAC investigation Operation Watts. Donnellan claims he never misused public funds but had previously breached party rules as Minister. He was replaced by Anthony Carbines on 6 December 2021.[18]
The Crisis Council of Cabinet was established on 3 April 2020 as a response to the COVID-19 pandemic. It consists of the premier and seven ministers who were all sworn in via video conference.[20] The Crisis Council of Cabinet and its positions were abolished in November that year.[21]