On 8 July 2017, Driussi joined Russian side Zenit Saint Petersburg on a four-year deal.[6] The transfer fee was €15 million.[7] He scored his first goal for Zenit on 22 July 2017 in a brace against FC Rubin Kazan.[8] His second goal came in the same game at stoppage time from a cross by teammate Domenico Criscito which helped them win their second fixture of the season under Roberto Mancini. On 4 May 2019, he scored a late equalizer in an away game against FC Akhmat Grozny that secured the 2018–19 Russian Premier League championship for Zenit.[9][10]
On 26 July 2021, Driussi bought out the remaining year of his contract with Zenit St.Petersburg, and left the club.[11]
Austin FC
Driussi signed with Major League Soccer club Austin FC on 29 July 2021 as a designated player.[12] He made his debut on 7 August 2021 against FC Dallas, coming on as a 62nd-minute substitute in the 2–0 defeat.[13] Driussi scored his first goal for the club on 21 August 2021 in a 3–1 home victory against the Portland Timbers.[14] On 16 April 2022, Driussi became the first Austin FC player to score 10 goals for the club in a comeback road win at D.C. United.
Driussi was named one of 26 players to make the 2022 MLS All-Star team.[15] On 14 February 2023, Driussi signed a new 3-year contract with Austin FC through the end of the 2025 season, with an option for the 2026 season.[16]