Scriptaid is a drug which acts as a histone deacetylase inhibitor, and was one of the first compounds discovered via high-throughput screening that acts at this target.[1] Scriptaid itself was never developed for medical applications, but led to the development of structurally related drugs such as vorinostat, which have been accepted into clinical use. Most early research using these compounds focused on their anti-cancer activity,[2] but more recent research has found scriptaid to be useful in other applications such as cloning and research into regulation of metabolism.[3][4][5][6]
References
^Su GH, Sohn TA, Ryu B, Kern SE (June 2000). "A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library". Cancer Research. 60 (12): 3137–42. PMID10866300.
^Zhu X, Nie J, Quan S, Xu H, Yang X, Lu Y, et al. (February 2016). "In vitro production of cloned and transgenically cloned embryos from Guangxi Huanjiang Xiang pig". In Vitro Cellular & Developmental Biology. Animal. 52 (2): 137–43. doi:10.1007/s11626-015-9957-0. PMID26559066. S2CID15676479.
^Rissi VB, Glanzner WG, Mujica LK, Antoniazzi AQ, Gonçalves PB, Bordignon V (February 2016). "Effect of Cell Cycle Interactions and Inhibition of Histone Deacetylases on Development of Porcine Embryos Produced by Nuclear Transfer". Cellular Reprogramming. 18 (1): 8–16. doi:10.1089/cell.2015.0052. PMID27281695.
