Allegedly built where Saint Ambrose would have stayed when in Florence in 393, the church is first recorded in 998, but is probably older. The church was rebuilt by Giovanni Battista Foggini in the 17th century.[1]
A legend says that on 30 December 1230 a chalice which had not been cleaned was, the next day, found to contain blood rather than wine by Uguccione, the parish priest. This Eucharistic miracle made the church a place of pilgrimage.
A marble altar in the Chapel of the Misericordia was designed by Mino da Fiesole; the same chapel has a fresco (1476) depicting events surrounding the miracle of the cup of wine by Cosimo Roselli.[2]