The primary storyline which was featured at Sacrifice was between defending champion Sting and Rob Van Dam for the TNA World Heavyweight Championship. At Lockdown Sting defeated both RVD and Mr. Anderson in a Three Way Steel Cage match to retain his championship after he pinned Anderson, also during the match RVD refused to hit Sting with steel pipe when Hulk Hogan gave it to him. On the following edition of Impact April 21, Sting chose RVD to be his opponent at Sacrifice due to his good actions at Lockdown.