STARD10

STARD10

STARD10
Identifiers
AliasesSTARD10, NY-CO-28, PCTP2, SDCCAG28, CGI-52, StAR related lipid transfer domain containing 10
External IDsOMIM: 617382; MGI: 1860093; GeneCards: STARD10
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

10809

56018

Ensembl

ENSG00000214530

ENSMUSG00000030688

UniProt

Q9Y365

Q9JMD3

RefSeq (mRNA)

NM_006645

NM_019990
NM_001360460

RefSeq (protein)

NP_006636

NP_064374
NP_001347389

Location (UCSC)Chr 11: 72.75 – 72.79 MbChr 7: 100.97 – 101 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

StAR-related lipid transfer protein 10 (STARD10) or PCTP-like protein is a lipid transfer protein that in humans is encoded by the STARD10 gene.[5][6] The protein derives its name from the fact that the molecule contains a START domain. As part of the StarD2 subfamily, StarD10 can transport the lipids phosphatidylcholine and phosphatidylethanolamine between membranes in solution.[7] Casein kinase II phosphorylates the protein on its serine at position 184.[8]

The function of StarD10 in the cell is not yet understood. Its expression is associated with cancer, but the nature of its role is unclear. Most recent data indicate that loss of StarD10 expression in breast cancer is associated with poor outcomes in patients.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000214530 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030688 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Türeci O, Sahin U, Pfreundschuh M, Old LJ (May 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". International Journal of Cancer. 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID 9610721. S2CID 916155.
  6. ^ "Entrez Gene: STARD10 START domain containing 10".
  7. ^ Olayioye MA, Vehring S, Müller P, Herrmann A, Schiller J, Thiele C, Lindeman GJ, Visvader JE, Pomorski T (July 2005). "StarD10, a START domain protein overexpressed in breast cancer, functions as a phospholipid transfer protein". The Journal of Biological Chemistry. 280 (29): 27436–42. doi:10.1074/jbc.M413330200. PMID 15911624.
  8. ^ Olayioye MA, Buchholz M, Schmid S, Schöffler P, Hoffmann P, Pomorski T (August 2007). "Phosphorylation of StarD10 on serine 284 by casein kinase II modulates its lipid transfer activity". The Journal of Biological Chemistry. 282 (31): 22492–8. doi:10.1074/jbc.M701990200. PMID 17561512.
  9. ^ Murphy NC, Biankin AV, Millar EK, McNeil CM, O'Toole SA, Segara D, Crea P, Olayioye MA, Lee CS, Fox SB, Morey AL, Christie M, Musgrove EA, Daly RJ, Lindeman GJ, Henshall SM, Visvader JE, Sutherland RL (March 2010). "Loss of STARD10 expression identifies a group of poor prognosis breast cancers independent of HER2/Neu and triple negative status". International Journal of Cancer. 126 (6): 1445–53. doi:10.1002/ijc.24826. PMID 19676041. S2CID 24623598.

Further reading

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