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National Library of Medicine Medical Subject Headings (MeSH) FactorBook SREBP2 This article incorporates text from the United States National Library of...
Click to read more »located on intron 16 of human sterol regulatory element-binding protein 2 (SREBP2) gene on chromosome 22 and intron 17 of SREBP1 gene on chromosome 17. miR-33a/b...
Click to read more »are associated with cholesterol homeostasis. They interact with the SCAP–SREBP2–INSIG complex tightly under cholesterol repletion conditions, thus keeping...
Click to read more »(2019-12-03). "Estrogen stimulates SREBP2 expression in hepatic cell lines via an estrogen response element in the SREBP2 promoter". Cellular & Molecular...
Click to read more »less well understood, but knocking out the cholesterol synthesis enzyme SREBP2 decreased Tau phosphorylation. Innate immunity triggers cholesterol synthesis...
Click to read more »senses and responds to excess cholesterol in the ER and acts together with SREBP2 as yin-yang to keep ER cholesterol levels within a safe, narrow range. The...
Click to read more »2006). "ABCA7 expression is regulated by cellular cholesterol through the SREBP2 pathway and associated with phagocytosis". Journal of Lipid Research. 47...
Click to read more »with Alzheimer's disease. When these proteins are active, they turn on SREBP2 which inhibits LRP-1. LRP-1 helps the brain remove amyloid beta. Therefore...
Click to read more »cholesterol diet. Increases in levels of either master gene regulator SREBP-1a or SREBP2, which both promote the production of proteins involved in cholesterol synthesis...
Click to read more »X, Li Y, Lu X, et al. (2010). "Interactions among genetic variants from SREBP2 activating-related pathway on risk of coronary heart disease in Chinese...
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