SMOX

54498

SMOX
SMOX
Identifiers
AliasesSMOX, C20orf16, PAO, PAO-1, PAO1, PAOH, PAOH1, SMO, spermine oxidase
External IDsOMIM: 615854; MGI: 2445356; GeneCards: SMOX
Enzyme activity
EC #BRENDAExPASyKEGGMetaCyc
1.5.3.16↗↗↗↗
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

54498

228608

Ensembl

ENSG00000088826

ENSMUSG00000027333

UniProt

Q9NWM0

Q99K82

RefSeq (mRNA)
RefSeq (protein)

NP_001257620
NP_787033
NP_787034
NP_787035
NP_787036

Location (UCSC)Chr 20: 4.12 – 4.19 MbChr 2: 131.49 – 131.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Spermine oxidase is an enzyme that in humans is encoded by the SMOX gene.[5][6][7]

Function

The product of this gene is the polyamine oxidase. This enzyme potentially represents a new class of catabolic enzymes in the mammalian polyamine metabolic pathway capable of the efficient oxidation of polyamines. More than five transcript variants encoding four active isoenzymes have been identified for this gene, however, not all variants have been fully described. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000088826 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027333 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wang Y, Devereux W, Woster PM, Stewart TM, Hacker A, Casero RA (July 2001). "Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure". Cancer Research. 61 (14): 5370–3. PMID 11454677.
  6. ^ Murray-Stewart T, Wang Y, Devereux W, Casero RA (December 2002). "Cloning and characterization of multiple human polyamine oxidase splice variants that code for isoenzymes with different biochemical characteristics". The Biochemical Journal. 368 (Pt 3): 673–7. doi:10.1042/BJ20021587. PMC 1223052. PMID 12398765.
  7. ^ a b "Entrez Gene: SMOX spermine oxidase".

Further reading

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