SERPINB8

SERPINB8
Identifiers
Aliases	SERPINB8, CAP2, PI8, serpin family B member 8, PSS5, PI-8, HMSD, HSMD-v, C18orf53
External IDs	OMIM: 601697; MGI: 894657; HomoloGene: 74445; GeneCards: SERPINB8; OMA:SERPINB8 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q22.1 Start 63,970,029 bp[1] End 64,019,779 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E2.1 Start 107,517,736 bp[2] End 107,538,214 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte skin of leg skin of abdomen granulocyte gallbladder islet of Langerhans gingival epithelium Descending thoracic aorta tibial arteries testicle Top expressed in lumbar spinal ganglion esophagus skin of external ear lip skin of back conjunctival fornix skin of abdomen stroma of bone marrow epidermis cervix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity protein binding serine-type endopeptidase inhibitor activity Cellular component cytoplasm cytosol extracellular exosome extracellular space collagen-containing extracellular matrix Biological process negative regulation of peptidase activity negative regulation of endopeptidase activity epithelial cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5271 20725 Ensembl ENSG00000166401 ENSMUSG00000026315 UniProt P50452 O08800 RefSeq (mRNA) NM_001031848 NM_001276490 NM_002640 NM_198833 NM_001348367 NM_001348368 NM_001348369 NM_001348370 NM_001366198 NM_001159748 NM_011459 RefSeq (protein) NP_001027018 NP_001263419 NP_002631 NP_942130 NP_001335296 NP_001335297 NP_001335298 NP_001335299 NP_001353127 NP_001153220 NP_035589 Location (UCSC) Chr 18: 63.97 – 64.02 Mb Chr 1: 107.52 – 107.54 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serpin B8 is a protein that in humans is encoded by the SERPINB8 gene.^[5][6][7]

See also

• Serpin

References

1. GRCh38: Ensembl release 89: ENSG00000166401 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026315 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sprecher CA, Morgenstern KA, Mathewes S, Dahlen JR, Schrader SK, Foster DC, Kisiel W (Jan 1996). "Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors". J Biol Chem. 270 (50): 29854–61. doi:10.1074/jbc.270.50.29854. PMID 8530382.
6. Bartuski AJ, Kamachi Y, Schick C, Overhauser J, Silverman GA (Nov 1997). "Cytoplasmic antiproteinase 2 (PI8) and bomapin (PI10) map to the serpin cluster at 18q21.3". Genomics. 43 (3): 321–8. doi:10.1006/geno.1997.4827. PMID 9268635.
7. "Entrez Gene: SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8".

Further reading

• Hubberstey A, Yu G, Loewith R, et al. (1997). "Mammalian CAP interacts with CAP, CAP2, and actin". J. Cell. Biochem. 61 (3): 459–66. doi:10.1002/(SICI)1097-4644(19960601)61:3<459::AID-JCB13>3.0.CO;2-E. PMID 8761950. S2CID 46076387.
• Dahlen JR, Foster DC, Kisiel W (1998). "Expression, purification, and inhibitory properties of human proteinase inhibitor". Biochemistry. 36 (48): 14874–82. doi:10.1021/bi970977p. PMID 9402754.
• Reddy PH, Stockburger E, Gillevet P, Tagle DA (1998). "Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method". Genomics. 46 (2): 174–82. doi:10.1006/geno.1997.5044. PMID 9417904.
• Dahlen JR, Jean F, Thomas G, et al. (1998). "Inhibition of soluble recombinant furin by human proteinase inhibitor 8". J. Biol. Chem. 273 (4): 1851–4. doi:10.1074/jbc.273.4.1851. PMID 9442015.
• Strik MC, Bladergroen BA, Wouters D, et al. (2003). "Distribution of the human intracellular serpin protease inhibitor 8 in human tissues". J. Histochem. Cytochem. 50 (11): 1443–54. doi:10.1177/002215540205001103. PMID 12417609.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hoetelmans RW (2004). "Nuclear partners of Bcl-2: Bax and PML". DNA Cell Biol. 23 (6): 351–4. doi:10.1089/104454904323145236. PMID 15231068.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Leblond J, Laprise MH, Gaudreau S, et al. (2006). "The serpin proteinase inhibitor 8: an endogenous furin inhibitor released from human platelets". Thromb. Haemost. 95 (2): 243–52. doi:10.1160/TH05-08-0561. PMID 16493485. S2CID 3620828.

External links

• The MEROPS online database for peptidases and their inhibitors: I04.013
• SERPINB8+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)