SENP8

1XT9, 2BKQ, 2BKR

SENP8
SENP8
Identifiers
AliasesSENP8, DEN1, NEDP1, PRSC2, SUMO/sentrin peptidase family member, NEDD8 specific, SUMO peptidase family member, NEDD8 specific
External IDsOMIM: 608659; MGI: 1918849; GeneCards: SENP8
Available structures
PDBOrtholog search: PDBe RCSB
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

123228

71599

Ensembl

ENSG00000166192

ENSMUSG00000051705

UniProt

Q96LD8

Q9D2Z4

RefSeq (mRNA)

NM_001166340
NM_001172109
NM_001172110
NM_001172111
NM_145204

NM_001172068
NM_001172069
NM_001172070
NM_001172071
NM_027838

RefSeq (protein)

NP_001159812
NP_001165580
NP_001165581
NP_001165582
NP_660205

NP_001165539
NP_001165540
NP_001165541
NP_001165542
NP_082114

Location (UCSC)Chr 15: 72.11 – 72.14 MbChr 9: 59.64 – 59.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sentrin-specific protease 8 is an enzyme that in humans is encoded by the SENP8 gene.[5][6][7]

NEDD8 (MIM 603171) is a ubiquitin-like protein that becomes conjugated to the cullin (see CUL1; MIM 603134) subunit of several ubiquitin ligases. This conjugation, called neddylation, is required for optimal ubiquitin ligase activity. NEDD8-specific deneddylases, such as NEDP1, or DEN1, are required to process the NEDD8 propeptide at a C-terminal diglycine motif and to remove NEDD8 from cullins (Gan-Erdene et al., 2003).[supplied by OMIM][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166192 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051705 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mendoza HM, Shen LN, Botting C, Lewis A, Chen J, Ink B, Hay RT (Jul 2003). "NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins". J Biol Chem. 278 (28): 25637–43. doi:10.1074/jbc.M212948200. PMID 12730221.
  6. ^ Gan-Erdene T, Nagamalleswari K, Yin L, Wu K, Pan ZQ, Wilkinson KD (Jul 2003). "Identification and characterization of DEN1, a deneddylase of the ULP family". J Biol Chem. 278 (31): 28892–900. doi:10.1074/jbc.M302890200. PMID 12759362.
  7. ^ a b "Entrez Gene: SENP8 SUMO/sentrin specific peptidase family member 8".

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q96LD8 (Sentrin-specific protease 8) at the PDBe-KB.


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