SAMD4A

SAMD4A
Identifiers
Aliases	SAMD4A, SAMD4, SMAUG, SMAUG1, SMG, SMGA, sterile alpha motif domain containing 4A
External IDs	OMIM: 610747; MGI: 1921730; GeneCards: SAMD4A
Gene location (Human)
Chr.	Chromosome 14 (human)
End	54,793,315 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	47,343,272 bp
RNA expression pattern
	Top expressed in
	dorsal motor nucleus of vagus nerve; ; inferior olivary nucleus; ; right ventricle; ; Skeletal muscle tissue of rectus abdominis; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; glutes; ; myocardium of left ventricle; ; left testis; ; tail of epididymis;
	Top expressed in
	seminiferous tubule; ; spermatid; ; tunica media of zone of aorta; ; soleus muscle; ; triceps brachii muscle; ; ankle; ; temporal muscle; ; digastric muscle; ; umbilical cord; ; myocardium of ventricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; translation repressor activity; mRNA binding; RNA binding;
Cellular component	cytoplasm; neuron projection; dendrite; cell projection; synapse; P-body; fibrillar center; cytosol; cell junction;
Biological process	regulation of translation; positive regulation of translation; negative regulation of translation; nuclear-transcribed mRNA poly(A) tail shortening; regulation of mRNA stability; regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	23034
	74480
	ENSG00000020577
	ENSMUSG00000021838
	Q9UPU9
	Q8CBY1
	NM_015589; NM_001161576; NM_001161577
	NM_001037221; NM_001163433; NM_028966; NM_001310544
	NP_001155048; NP_001155049; NP_056404
	NP_001032298; NP_001156905; NP_001297473; NP_083242
	Wikidata
View/Edit Human	View/Edit Mouse

Sterile alpha motif domain containing 4A is a protein that in humans is encoded by the SAMD4A gene.^[5]

Function

Sterile alpha motifs (SAMs) in proteins such as SAMD4A are part of an RNA-binding domain that functions as a posttranscriptional regulator by binding to an RNA sequence motif known as the Smaug recognition element, which was named after the Drosophila Smaug protein (Baez and Boccaccio, 2005 [PubMed 16221671]).[supplied by OMIM, Mar 2008].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000020577 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021838 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Sterile alpha motif domain containing 4A". Retrieved 2020-04-16.

Baez MV, Boccaccio GL (December 2005). "Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules". J. Biol. Chem. 280 (52): 43131–40. doi:10.1074/jbc.M508374200. hdl:20.500.12110/paper_00219258_v280_n52_p43131_Baez. PMID 16221671.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (October 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000020577 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021838 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Sterile alpha motif domain containing 4A". Retrieved 2020-04-16.

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SAMD4A

Function

References

Further reading

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