S9632

S9632

S9632
Identifiers
  • 4-amino-5-[2,2-dimethyl-3-oxo-3-(propan-2-ylamino)propoxy]-2-methylquinoline-3-carboxylic acid
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC19H25N3O4
Molar mass359.426 g·mol−1
3D model (JSmol)
  • CC1=C(C(=C2C(=N1)C=CC=C2OCC(C)(C)C(=O)NC(C)C)N)C(=O)O
  • InChI=1S/C19H25N3O4/c1-10(2)21-18(25)19(4,5)9-26-13-8-6-7-12-15(13)16(20)14(17(23)24)11(3)22-12/h6-8,10H,9H2,1-5H3,(H2,20,22)(H,21,25)(H,23,24)
  • Key:RHXLOOCFQPJWBW-UHFFFAOYSA-N

S9632 (FEMA 4774) is a food additive which acts as a positive allosteric modulator of the TAS1R2/TAS1R3 heterodimer that is the primary sweet taste receptor in humans. It is described as a flavour modifier, having little taste of its own but causing sweet flavours to taste sweeter and enhancing certain aspects of the flavour profile. It was approved for use in food in 2012 and is used in various countries including the United States, Japan, South Korea, and Mexico.[1][2]

See also

References

  1. ^ Arthur AJ, Karanewsky DS, Liu H, Chi B, Markison S (2015). "Toxicological evaluation of the flavour ingredient 4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid". Toxicology Reports. 2: 1255–1264. Bibcode:2015ToxR....2.1255A. doi:10.1016/j.toxrep.2015.08.012. PMC 5598146. PMID 28962468.
  2. ^ Chéron JB, Soohoo A, Wang Y, Golebiowski J, Antonczak S, Jiang P, et al. (May 2019). "Conserved Residues Control the T1R3-Specific Allosteric Signaling Pathway of the Mammalian Sweet-Taste Receptor". Chemical Senses. 44 (5): 303–310. doi:10.1093/chemse/bjz015. PMC 6538948. PMID 30893427.
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