Guzmán spent the 2017 season with the Triple–A Round Rock Express, posting a stat line of .298/.372/.434/.806 with 12 home runs and 62 RBIs. After the 2017 season, the Rangers organization named him their 2017 Tom Grieve Player of the Year (minor league).[9] Guzmán returned to the Round Rock Express to start the 2018 season, playing in 5 games with them before being recalled to the major leagues for the first time.
Major leagues
The Rangers promoted Guzmán to the major leagues on April 13, 2018.[10] He hit his first major league home run on April 14, 2018, to tie a game against the Houston Astros in the top of the eighth inning. On August 10, 2018, he became the first rookie to ever hit three home runs against the New York Yankees in the Bronx. It was his father's first time seeing his son play in a professional game.[11] Guzmán finished his rookie season with a .235/.306/.416/.722 batting line with 16 home runs and 58 RBIs in 123 games.
Coming out of spring training in 2019, Guzmán was named the Rangers' starting first baseman. However, he was placed on the 10-day injured list on April 7, 2019, with a right hamstring strain.[12] He was reactivated off the IL on May 9, starting at first base that night.[13] However, after posting a .193/.282/.396/.678 battling line during the first four months of the season, he was optioned to Triple-A Nashville on July 23.[14] After slashing an impressive .316/.409/.518/.927 batting line at Nashville, he was called up on September 1 to become the Rangers' everyday first baseman.[15] Guzmán would finish the 2019 season batting .219/.308/.414/.723 with 10 home runs and 36 RBIs in 87 games.
On April 12, 2021, his first career start in left field and the outfield, Guzmán tore the meniscus in his right knee and was placed on the 10-day injured list the next day. He had been batting .063/.118/.250 in 17 plate appearances at the time of his injury.[17] On April 23, Guzmán underwent season-ending right knee surgery.[18] On April 26, he was placed on the 60-day injured list.[19] Guzmán was outrighted off of the 40-man roster on November 5,[20] and elected free agency the following day.
The Yankees promoted Guzmán to the major leagues on September 7.[23] On September 10, Guzmán was designated for assignment after going 0-for-6 with 5 strikeouts in limited action. He cleared waivers and was sent outright to Triple–A Scranton on September 12.[24] On October 24, Guzmán elected free agency.
San Francisco Giants
On January 16, 2023, Guzmán signed a minor league contract with the San Francisco Giants.[25] On February 6, Guzmán was invited to Spring Training and announced as both a pitcher and infielder.[26] On March 14, it was announced that Guzmán would miss 6-8 weeks after suffering a pronator strain in his left forearm.[27] On August 20, Guzmán began a rehab assignment with the rookie–level Arizona Complex League Giants.[28] After three games, he was released by the Giants organization on August 26. [29]
Baltimore Orioles
On January 25, 2024, Guzmán signed a minor league contract with the Baltimore Orioles.[30] In 8 games split between the rookie–level Florida Complex League Orioles and High–A Aberdeen IronBirds, he struggled to a 13.50 ERA with 11 strikeouts and one save across 7+1⁄3 innings pitched. Guzmán was released by the Orioles organization on October 5.[31]
Personal life
In 2014, Guzman was home in the Dominican Republic driving his vehicle when he collided with a motorcycle. The crash resulted in the death of the driver of the motorcycle. Guzman did not face any charges from the incident, as the police determined that the motorcycle driver had failed to stop at an intersection.[32] Guzman has one daughter, named Charlotte.[11]