Curzon married the Honourable Harriet Anne, eldest daughter of Cecil Bisshopp, 12th Baron Zouche of Parham, in 1808. The barony of Zouche fell into abeyance on Lord Zouche's death in 1828 but was called out of abeyance the following year in favour of Harriet Anne (who became known as the Baroness de la Zouche).
Curzon inherited Hagley Hall, Worcestershire and other unentailed properties on the death of his father in 1820 and acquired Parham Park in trust on the death of his father-in-law in 1828.
Curzon died at Parham Park in May 1863, leaving 2 sons, and was buried at Parham. Lady de la Zouche died in May 1870 and was succeeded by their elder son, Robert, who had previously succeeded his father as Member of Parliament for Clitheroe in 1831.[2] In his will Curzon directed that the Hagley estate should be sold to provide an income for his younger son, the barrister Edward Cecil Curzon.
Curzon owned a copy of the Third Folio of Shakespeare's works, containing what may be the only copy of a Portrait of Anne Hathaway, Shakespeare's wife.