Richard L. Lieber

For other people named Richard Lieber, see Richard Lieber.
Rick Lieber
Born
Richard L. Lieber

Walnut Creek, California
Alma materUniversity of California, Davis (BS, Ph.D) University of California, San Diego (Postdoc, MBA)
Scientific career
FieldsPhysiology, Anatomy, Biology, Biomedical Engineering
InstitutionsShirley Ryan AbilityLab Northwestern University
Websitehttps://www.sralab.org/researchers/richard-lieber-phd

Richard (Rick) L. Lieber (born December 14, 1956) is an American scientist in the field of muscle physiology who is an internationally recognized expert in skeletal muscle structure and function.[1][2][3] His research focuses on skeletal muscle properties in individuals with neurological disorders such as spinal cord injury or cerebral palsy to identify targets for therapeutic interventions.[4][5][6][7][8]

Early life and education

Dr. Lieber was born in Walnut Creek, California, the son of a big band musician and hospital administrator. He completed a B.S. in physiology in 1978 at University of California, Davis.[9] In 1983, he earned his Ph.D. in biophysics from University of California, Davis, applied a theory of light diffraction to study mechanical properties of muscle cells[10] and was one of the first to use the Intel 8080 microprocessor to control a biological system in real-time.[11]  He received his M.B.A. in 2013 from Rady School of Management, University of California, San Diego.

Career

Lieber started his career as a Biomedical Engineer at the Veterans Administration Medical Center (1983) and then started in academia at UC San Diego (1985). Notably, he holds the position of Chief Scientific Officer at Shirley Ryan AbilityLab (formerly the Rehabilitation Institute of Chicago), a nationally recognized translational rehabilitation research hospital[12].

Research

Lieber has published over 350 articles in peer-reviewed scientific journals ranging from basic science such as The Journal of Cell Biology[13] to clinical research such as The Journal of Hand Surgery.[14][15][16] He is an established expert in using biological approaches to understand muscle contractures in neurological conditions such as cerebral palsy, stroke and spinal cord injury. Lieber's work includes the development of pharmacological and surgical interventions to improve muscle function in individuals with neurological conditions.[17][18][19] He has made significant contributions to the field of muscle physiology in the area of in vivo muscle measurements,[20][21] and he is highly referenced in scientific journals.[22] His most often cited paper is "Functional and clinical significance of skeletal muscle architecture" in the peer-reviewed journal Muscle & Nerve with 1447 citations. His work has over 34,000 citations in the scientific community and his h-index is 91.[23] In addition to his publications in peer-reviewed journals, he authored the textbook, "Skeletal Muscle Structure, Function, and Plasticity," which explores basic and applied physiological properties of skeletal muscle.[24]

Distinctions

Lieber's career is marked by significant professional collaborations with international colleagues and organizations, including Jan Fridén, M.D., Ph.D. at Gothenburg University,[25][26] Eva Pontén at the Karolinska Institute,[27] and Allistair Rothwell at Christ Church, New Zealand.[28]

Lieber also serves as a member of the scientific advisory board of the NFL[29] and has six patents on surgical techniques, methods to measure muscle fibers, and methods to administer stimulation to skeletal muscles[30]

Awards and honors

Lieber has received a number of awards and honors throughout his career. These include:

Elsass Foundation Research Prize, June 2023[31][32]

Paul B. Magnuson Award, Rehabilitation Research and Development, Department of Veterans Affairs, March 2023[33][34]

Goel Award for Translational Biomechanics, North American Congress on Biomechanics (NACOB), American Society for Biomechanics, August 2022, Ottawa, Ontario, Canada.[35]

Lifetime Achievement Award, American Academy of Cerebral Palsy and Developmental Medicine,[36][37] 2021

Fellow, Orthopaedic Research Society (ORS), November 2020[38][39]

Fellow, American Institute of Medical and Biological Engineering (AIMBE), March 2019[40]

Hay Award in Sport Biomechanics, American Society of Biomechanics, August 2017[35][41]

Honorary Member, American Physical Therapy Association, February 2015[42]

Founders Award, American College of Sports Medicine (Southwest Chapter), October 2014.[41][43]

Gayle G. Arnold Award, American Academy of Cerebral Palsy and Developmental Medicine, October 2013[36]

Kappa Delta Award, American Academy of Orthopaedic Surgeons, February 2013, Chicago, IL.[44][45]

Fellow, American Society for Biomechanics, July 2012[46]

Outstanding Research Award, International Society for the Study of the Lumbar Spine (ISSLS), Göteborg, Sweden. June 2011.[47]

Giovanni Borelli Award, American Society of Biomechanics, August, 2007.[48]

The Göteborg University Medal, Sahlgrenska University Hospital, June 2007.[49][3]

Fulbright Scholarship (Sweden), 2007[50]

Nicolas Andry Award, American Bone and Joint Surgeons, Vancouver, British Columbia, Canada, May 2002[51][52]

Fellow, American College of Sports Medicine, March, 1994.[53]

Kappa Delta Young Investigator Award, American Academy of Orthopaedic Surgeons, February 1994.[44]

Publications

Selected publications[54]

  1. Lieber, R.L. and R.J. Baskin. (1983). Intersarcomere dynamics of single skeletal muscle fibers during fixed-end tetani. J. Gen. Physiol. 82:347-364. PMC2228698.
  2. Lieber, R.L., R.J. Baskin and Y. Yeh. (1984). Sarcomere length determination using laser diffraction: effect of beam and fiber diameter. Biophys. J. 45:1007-1016. PMC1434983.
  3. Lieber RL, Yeh Y, Baskin RJ. Sarcomere length determination using laser diffraction. Effect of beam and fiber diameter. Biophysical Journal. 1984;45:1007-16
  4. Lieber, R.L. and J.L. Boakes. (1988). Sarcomere length and joint kinematics during torque production in the frog hindlimb. Am. J. Physiol. 254:C759-C768. PMID3259840
  5. Lieber, R.L. and F.T. Blevins. (1989). Skeletal muscle architecture of the rabbit hindlimb: Functional implications of muscle design. J. Morphol. 199:93-101. PMID2921772
  6. Lieber, R.L., M.E. Leonard, C.G. Brown, and C.L. Trestik. (1991). Frog semitendinosis  tendon load-strain and stress-strain properties during passive loading. Am. J. Physiol. 261:C86-C92. PMID1858862
  7. Lieber, R.L., Raab, R., Kashin, S. and V.R. Edgerton (1992). Sarcomere length changes during fish swimming. J. Exp. Biol. 169:251-254. PMID11536506
  8. Lieber RL, Baskin RJ, Yeh Y.  (1984).  Sarcomere length determination using laser diffraction: effect of beam and fiber diameter. Biophys. J. 45:1007-1016. PMC 434983
  9. Lieber, R.L. G.J. Loren and J. Fridén. (1994). In vivo measurement of human wrist extensor muscle sarcomere length changes. J. Neurophysiol. 71:874-881. PMID8201427
  10. Sam M, Shah S, Fridén J, Milner DJ, Capetanaki Y, Lieber RL.  (2000). Desmin knockout muscles generate lower stress and are less vulnerable to injury compared to wildtype muscles.  Am. J. Physiol. 279:C1116-1122. PMID 1003592.
  11. Sam, M., S. Shah, J. Fridén, D.J. Milner, Y. Capetanaki and R.L. Lieber. (2000). Desmin knockout muscles generate lower stress and are less vulnerable to injury compared to wildtype muscles. Am. J. Physiol. 279:C1116-1122. PMID11003592
  12. Lieber, R.L. and J. Fridén. (2002). Spasticity causes a fundamental rearrangement of muscle-joint interaction. Muscle & Nerve 25:265-270. PMID11870696
  13. Lieber, R.L., J. Fridén, T. Hobbs, A.G. Rothwell. (2003). Analysis of posterior deltoid function one year after surgical restoration of elbow extension. J. Hand. Surg. (Am.) 28A:288-293. PMID 12671862.
  14. Patel, T.J., R. Das, J. Fridén, G.J. Lutz and R.L. Lieber. (2004). Sarcomere strain and heterogeneity correlate with injury to frog skeletal muscle fiber bundles. J. Appl. Physiol. 97:1803-1813. PMID15208284
  15. Lieber, R.L., W. Murray, D.L. Clark, V.R. Hentz and J. Fridén. (2005). Biomechanical properties of the brachioradialis muscle: Implications for surgical tendon transfer. J. Hand Surg. (Am.) 30:273-282. PMID15781349.
  16. Hentzen, E.R., M. Lahey, D. Peters, L. Mathew, I.A. Barash, J. Fridén and R.L. Lieber. (2006).  Stress-dependent and -independent expression of the myogenic regulatory factors and the MARP genes after eccentric contractions in rats. J. Physiol. (Lond.) 570:157-167. PMC1464283
  17. Smith, L.R., K.S. Lee, S.R. Ward, H.G. Chambers, R.L. Lieber. (2011) Hamstring contractures in children with spastic cerebral palsy result from a stiffer ECM and increased in vivo sarcomere length. J. Physiol. (Lond.) 589:2625-2639. PMID 21486759.
  18. Palmisano, M.G., S.N. Bremner, S. Huang, A.A. Domenighetti, T. Hornberger, S.B. Shah, M. Kellermeyer, A.F. Ryan, and R.L. Lieber. (2014). Skeletal muscle intermediate filaments  act as a stress-transmitting and stress-transducing signaling network. J. Cell Sci.128:219-224. PMC4294770
  19. Young KW, Radic S, Myslivets E, Lieber RL. (2014). Resonant reflection spectroscopy of biomolecular arrays in muscle.  Biophys. J. 107:2352-2360. PMID 25418304.
  20. Young, K.W., S. Radic, E. Myslivets, and R.L. Lieber. (2014). Resonant reflection spectroscopy of biomolecular arrays in muscle. Biophys. J. 107:2352-2360. PMC4241457.
  21. Palmisano, M.G., S.N. Bremner, A.A. Domenighetti, T. Hornberger, S.B. Shah, M. Kellermeyer, A.F. Ryan, and R.L. Lieber. (2014). Skeletal muscle intermediate filaments act as a stress-transmitting and stress-transducing signaling network. J. Cell Sci. 128:219-224. PMID 25413344.
  22. Mathewson, M.A., S.R. Ward, H.G. Chambers and R.L. Lieber. (2014). High resolution muscle measurements provide insight into equinus contracture in patients with cerebral palsy. J. Orthop Res. 33:33-39. PMC2903973
  23. Young, K.W., B.P.P Kuo, S.M. O'Connor, S. Radic and R.L. Lieber. (2017). In vivo sarcomere length measurement in whole muscles during passive stretch and twitch  contractions. Biophys. J. 112:805-812. PMID 28256239.
  24. Domenighetti, A., M.A. Mathewson, R. Pichika, L. Zhao, H.G. Chambers and R.L. Lieber. (2018). Loss of myogenic potential and fusion capacity of satellite cells isolated from contractured muscle in children with cerebral palsy. Am. J. Physiol. 315:C247-C257. PMID 29694232.

References

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  3. ^ a b "Contributors". IAACD. 2019-07-29. Retrieved 2023-11-06.
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  5. ^ Son, Jongsang; Fridén, Jan; Lieber, Richard L. (2022). "Biomechanical Modeling of Brachialis-to-Wrist Extensor Muscle Transfer Function for Daily Activities in Tetraplegia". JB & JS Open Access. 7 (3): e22.00018. doi:10.2106/JBJS.OA.22.00018. ISSN 2472-7245. PMC 9302328. PMID 35923813.
  6. ^ Moreau, Noelle G.; Lieber, Richard L. (2022). "Effects of voluntary exercise on muscle structure and function in cerebral palsy". Developmental Medicine and Child Neurology. 64 (6): 700–708. doi:10.1111/dmcn.15173. ISSN 1469-8749. PMC 9086177. PMID 35142371.
  7. ^ Fridén, Jan; Stankovic, Nenad; Ward, Samuel R.; Lieber, Richard L. (2022). "Increased muscle fiber size and pathology with botulinum toxin treatment of upper extremity muscles in cerebral palsy". Current Topics in Toxicology. 18: 167–178. ISSN 0972-8228. PMC 10049878. PMID 36999118.
  8. ^ Winters, Taylor M.; Lim, Michael; Takahashi, Mitsuhiko; Fridén, Jan; Lieber, Richard L.; Ward, Samuel R. (2021). "Surgical Mobilization of Skeletal Muscles Changes Functional Properties-Implications for Tendon Transfers". The Journal of Hand Surgery. 46 (4): 341.e1–341.e10. doi:10.1016/j.jhsa.2020.09.017. ISSN 1531-6564. PMID 33243591. S2CID 227181052.
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  14. ^ Lieber, Richard L. (2008-11-01). "Biology and Mechanics of Skeletal Muscle: What Hand Surgeons Need to Know When Tensioning a Tendon Transfer". The Journal of Hand Surgery. 33 (9): 1655–1656. doi:10.1016/j.jhsa.2008.08.010. ISSN 0363-5023. PMID 18984353.
  15. ^ "Lieber, Richard L. | Learning For Life". www.nulearningforlife.org. Retrieved 2023-11-06.
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  17. ^ "Clinical repurposing trials for COVID-19 and cerebral palsy underway in Chicago; trials at the University of Chicago, Northwestern University and Shirley Ryan AbilityLab demonstrate Chicago's continued biomedical strength". Daily Herald. 2020-09-29. Retrieved 2023-11-06.
  18. ^ "Cancer Drug Shows Promise in Treatment of Cerebral Palsy". www.sralab.org. 2018-04-26. Retrieved 2023-11-06.
  19. ^ Gardenier, Jason; Garg, Rohit; Mudgal, Chaitanya (2020). "Upper Extremity Tendon Transfers: A Brief Review of History, Common Applications, and Technical Tips". Indian Journal of Plastic Surgery. 53 (2): 177–190. doi:10.1055/s-0040-1716456. ISSN 0970-0358. PMC 7458847. PMID 32884184.
  20. ^ Iyer, Shama R.; Valencia, Ana P.; Hernández-Ochoa, Erick O.; Lovering, Richard M. (2016). "In Vivo Assessment of Muscle Contractility in Animal Studies". Skeletal Muscle Regeneration in the Mouse. Methods in Molecular Biology (Clifton, N.J.). Vol. 1460. pp. 293–307. doi:10.1007/978-1-4939-3810-0_20. ISBN 978-1-4939-3808-7. ISSN 1064-3745. PMC 5500964. PMID 27492180.
  21. ^ Đorđević, Srđan; Tomažič, Sašo; Narici, Marco; Pišot, Rado; Meglič, Andrej (2014-09-25). "In-Vivo Measurement of Muscle Tension: Dynamic Properties of the MC Sensor during Isometric Muscle Contraction". Sensors (Basel, Switzerland). 14 (9): 17848–17863. Bibcode:2014Senso..1417848D. doi:10.3390/s140917848. ISSN 1424-8220. PMC 4208254. PMID 25256114.
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  33. ^ "Hines VA senior research scientist receives Magnuson Award | VA Hines health care". Veterans Affairs. 2023-03-03. Retrieved 2023-11-06.
  34. ^ "Lieber Receives VA Rehabilitation Research and Development Award". News Center. 2023-03-13. Retrieved 2023-11-06.
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  54. ^ "Faculty Profile". www.feinberg.northwestern.edu. Retrieved 2023-07-06.

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