RFFL
E3 ubiquitin-protein ligase RFFL (Ring Finger And FYVE Like Domain Containing E3 Ubiquitin) is a ubiquitin ligase enzyme that in humans is encoded by the RFFL gene.[5][6] RFFL associates with endosomes.[7] RFFL is known to affect cardiac repolarization,[8] Cystic fibrosis transmembrane conductance regulator (CFTR) ubiquitination,[9] and mitochondrial clearance by affecting Parkin/PRKN recruitment.[7]
Interactors
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000092871 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020696 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Coumailleau F, Das V, Alcover A, Raposo G, Vandormael-Pournin S, Le Bras S, et al. (October 2004). "Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment". Molecular Biology of the Cell. 15 (10): 4444–4456. doi:10.1091/mbc.E04-04-0274. PMC 519139. PMID 15229288.
- ^ "Entrez Gene: RFFL ring finger and FYVE-like domain containing 1".
- ^ a b Ravindran R, Velikkakath AK, Narendradev ND, Chandrasekharan A, Santhoshkumar TR, Srinivasula SM (December 2022). "Endosomal-associated RFFL facilitates mitochondrial clearance by enhancing PRKN/parkin recruitment to mitochondria". Autophagy. 18 (12): 2851–2864. doi:10.1080/15548627.2022.2052460. PMC 9673925. PMID 35373701.
- ^ Kabakov AY, Roder K, Bronk P, Turan NN, Dhakal S, Zhong M, et al. (March 2024). "E3 ubiquitin ligase rififylin has yin and yang effects on rabbit cardiac transient outward potassium currents (Ito) and corresponding channel proteins". The Journal of Biological Chemistry. 300 (3) 105759. doi:10.1016/j.jbc.2024.105759. PMC 10945274. PMID 38367666.
- ^ Okiyoneda T, Veit G, Sakai R, Aki M, Fujihara T, Higashi M, et al. (March 2018). "Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase". Developmental Cell. 44 (6): 694–708.e7. doi:10.1016/j.devcel.2018.02.001. PMC 6447300. PMID 29503157.
Further reading
- Tibbetts MD, Shiozaki EN, Gu L, McDonald ER, El-Deiry WS, Shi Y (December 2004). "Crystal structure of a FYVE-type zinc finger domain from the caspase regulator CARP2". Structure. 12 (12): 2257–2263. doi:10.1016/j.str.2004.10.007. PMID 15576038.
- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- McDonald ER, El-Deiry WS (April 2004). "Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth". Proceedings of the National Academy of Sciences of the United States of America. 101 (16): 6170–6175. Bibcode:2004PNAS..101.6170M. doi:10.1073/pnas.0307459101. PMC 395941. PMID 15069192.
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