RBM5

RBM5
Identifiers
Aliases	RBM5, G15, LUCA15, RMB5, H37, RNA binding motif protein 5, LUCA-15
External IDs	OMIM: 606884; MGI: 1933204; GeneCards: RBM5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LK0, 2LK1, 2LKZ
Gene location (Human)
Chr.	Chromosome 3 (human)
End	50,119,021 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	107,648,195 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; sural nerve; ; Achilles tendon; ; left ovary; ; right ovary; ; right lobe of thyroid gland; ; canal of the cervix; ; left lobe of thyroid gland; ; right hemisphere of cerebellum; ; anterior pituitary;
	Top expressed in
	Rostral migratory stream; ; genital tubercle; ; medullary collecting duct; ; tail of embryo; ; saccule; ; neural layer of retina; ; vestibular sensory epithelium; ; thymus; ; vestibular membrane of cochlear duct; ; lymph node;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; metal ion binding; protein binding; nucleic acid binding; mRNA binding; RNA binding;
Cellular component	nucleoplasm; spliceosomal complex; nucleus;
Biological process	regulation of apoptotic process; mRNA splicing, via spliceosome; RNA processing; mRNA processing; regulation of alternative mRNA splicing, via spliceosome; spliceosomal complex assembly; positive regulation of apoptotic process; negative regulation of cell population proliferation; apoptotic process; RNA splicing;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10181
	83486
	ENSG00000003756
	ENSMUSG00000032580
	P52756
	Q91YE7
	NM_005778
	NM_148930; NM_001359524; NM_001359525; NM_001359526
	NP_005769
	NP_683732; NP_001346453; NP_001346454; NP_001346455
	Wikidata
View/Edit Human	View/Edit Mouse

RNA-binding protein 5 is a protein that in humans is encoded by the RBM5 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000003756 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032580 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Timmer T, Terpstra P, van den Berg A, Veldhuis PM, Ter Elst A, Voutsinas G, Hulsbeek MM, Draaijers TG, Looman MW, Kok K, Naylor SL, Buys CH (Aug 1999). "A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3". Eur J Hum Genet. 7 (4): 478–486. doi:10.1038/sj.ejhg.5200334. PMID 10352938.
^ "Entrez Gene: RBM5 RNA binding motif protein 5".

Timmer T, Terpstra P, van den Berg A, et al. (1999). "An evolutionary rearrangement of the Xp11.3-11.23 region in 3p21.3, a region frequently deleted in a variety of cancers". Genomics. 60 (2): 238–240. doi:10.1006/geno.1999.5878. PMID 10486216.
Oh JJ, Grosshans DR, Wong SG, Slamon DJ (1999). "Identification of differentially expressed genes associated with HER-2/neu overexpression in human breast cancer cells". Nucleic Acids Res. 27 (20): 4008–4017. doi:10.1093/nar/27.20.4008. PMC 148668. PMID 10497265.
Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–464. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479. S2CID 21839750.
Sutherland LC, Edwards SE, Cable HC, et al. (2000). "LUCA-15-encoded sequence variants regulate CD95-mediated apoptosis". Oncogene. 19 (33): 3774–3781. doi:10.1038/sj.onc.1203720. PMID 10949932.
Oh JJ, West AR, Fishbein MC, Slamon DJ (2002). "A candidate tumor suppressor gene, H37, from the human lung cancer tumor suppressor locus 3p21.3". Cancer Res. 62 (11): 3207–3213. PMID 12036935.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mourtada-Maarabouni M, Sutherland LC, Meredith JM, Williams GT (2003). "Simultaneous acceleration of the cell cycle and suppression of apoptosis by splice variant delta-6 of the candidate tumour suppressor LUCA-15/RBM5". Genes Cells. 8 (2): 109–119. doi:10.1046/j.1365-2443.2003.00619.x. PMID 12581154. S2CID 24099427.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Rintala-Maki ND, Sutherland LC (2005). "LUCA-15/RBM5, a putative tumour suppressor, enhances multiple receptor-initiated death signals". Apoptosis. 9 (4): 475–484. doi:10.1023/B:APPT.0000031455.79352.57. PMID 15192330. S2CID 9436571.
Rintala-Maki ND, Abrasonis V, Burd M, Sutherland LC (2005). "Genetic instability of RBM5/LUCA-15/H37 in MCF-7 breast carcinoma sublines may affect susceptibility to apoptosis". Cell Biochem. Funct. 22 (5): 307–313. doi:10.1002/cbf.1106. PMID 15338470. S2CID 41472130.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–968. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Mourtada-Maarabouni M, Keen J, Clark J, et al. (2006). "Candidate tumor suppressor LUCA-15/RBM5/H37 modulates expression of apoptosis and cell cycle genes". Exp. Cell Res. 312 (10): 1745–1752. doi:10.1016/j.yexcr.2006.02.009. PMID 16546166.
Oh JJ, Razfar A, Delgado I, et al. (2006). "3p21.3 tumor suppressor gene H37/Luca15/RBM5 inhibits growth of human lung cancer cells through cell cycle arrest and apoptosis". Cancer Res. 66 (7): 3419–3427. doi:10.1158/0008-5472.CAN-05-1667. PMID 16585163.
Masdeu C, Faure H, Coulombe J, et al. (2006). "Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15". Biochem. Biophys. Res. Commun. 349 (2): 471–479. doi:10.1016/j.bbrc.2006.07.216. PMID 16945339.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

RBM5 human gene location in the UCSC Genome Browser.
RBM5 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000003756 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032580 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10352938-5] Timmer T, Terpstra P, van den Berg A, Veldhuis PM, Ter Elst A, Voutsinas G, Hulsbeek MM, Draaijers TG, Looman MW, Kok K, Naylor SL, Buys CH (Aug 1999). "A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3". Eur J Hum Genet. 7 (4): 478–486. doi:10.1038/sj.ejhg.5200334. PMID 10352938.

[entrez-6] "Entrez Gene: RBM5 RNA binding motif protein 5".

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RBM5

References

Further reading

External links

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