The hospital was commissioned to replace the Milesmark Hospital, the Dunfermline and West Fife District Hospital and the Dunfermline Maternity Hospital. The first phase of the new hospital, which excluded maternity services, opened in 1985. The second phase was completed in 1993 and the new facilities were officially opened by the Princess Royal later that year.[1][2]
From January 2012, all of Fife's accident and emergency services were located at the Victoria Hospital in Kirkcaldy.[3] In 2014 improvements were made to the reception area aimed at making the area more welcoming.[4]