Since Autoroute 55 closely parallels Route 143 for most of its length, much commercial traffic chooses the former. However, it is a very busy route and takes much traffic from the border to the Sherbrooke local area. Route 143 closely follows the Saint-François River between Sherbrooke and Ulverton.
The road is often in notoriously poor condition, since its original cement was laid directly on a gravel road in the mid-1920s. It has been extensively resurfaced to the point the pavement is now more than three feet thick in places, but it heaves extensively at every spring thaw.
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