Protein phosphatase with ef-hand domain 2

PPEF2
Identifiers
Aliases	PPEF2, PPP7CB, protein phosphatase with EF-hand domain 2
External IDs	OMIM: 602256; MGI: 1342304; HomoloGene: 55959; GeneCards: PPEF2; OMA:PPEF2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.1 Start 75,859,864 bp[1] End 75,902,571 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E2 Start 92,374,538 bp[2] End 92,404,137 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gastrocnemius muscle right uterine tube right hemisphere of cerebellum mucosa of transverse colon left uterine tube Descending thoracic aorta left ovary body of uterus monocyte Top expressed in neural layer of retina retinal pigment epithelium epithelium of lens pineal gland embryo morula embryo tail of embryo lumbar subsegment of spinal cord zygote More reference expression data BioGPS n/a
Gene ontology Molecular function iron ion binding Hsp90 protein binding calcium ion binding phosphoprotein phosphatase activity manganese ion binding mitogen-activated protein kinase kinase kinase binding protein serine/threonine phosphatase activity metal ion binding Hsp70 protein binding hydrolase activity protein binding Cellular component cytoplasm cell projection photoreceptor inner segment photoreceptor outer segment cilium cytosol nucleus Biological process detection of stimulus involved in sensory perception response to stimulus negative regulation of peptidyl-threonine phosphorylation protein dephosphorylation negative regulation of MAPK cascade regulation of MAP kinase activity visual perception regulation of JUN kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5470 19023 Ensembl ENSG00000156194 ENSMUSG00000029410 UniProt O14830 O35385 RefSeq (mRNA) NM_006239 NM_152933 NM_152934 NM_011148 RefSeq (protein) NP_006230 NP_035278 Location (UCSC) Chr 4: 75.86 – 75.9 Mb Chr 5: 92.37 – 92.4 Mb PubMed search [3] [4]
Wikidata
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Protein phosphatase with EF-hand domain 2 is a protein that in humans is encoded by the PPEF2 gene. ^[5]

Function

This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein, which is expressed specifically in photoreceptors and the pineal, has been suggested to play a role in the visual system. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. [provided by RefSeq, Jul 2008].

References

1. GRCh38: Ensembl release 89: ENSG00000156194 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029410 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Protein phosphatase with EF-hand domain 2". Retrieved 2018-02-08.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.